STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE)

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HASSANPOUR SEYYED HOSSEIN; DEHGHANI MOHAMMAD AMIN; KARAMI SEYYEDEH ZEINAB

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Journal Paper

Paper Information

Journal: Journal of Cardiovascular and Thoracic Research Year:2018 | Volume:10 | Issue:1 Page(s): 1-13

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Information Journal Paper

Title

STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE)

Author(s)

HASSANPOUR SEYYED HOSSEIN | DEHGHANI MOHAMMAD AMIN | KARAMI SEYYEDEH ZEINAB | Issue Writer Certificate

Keywords

BEATING HEART

METABOLIC

RESPIRATORY CHAIN

MITOCHONDRIAL

CARDIAC DISORDERS

Abstract

The relentlessly BEATING HEART has the greatest oxygen consumption of any organ in the body at rest reflecting its huge METABOLIC turnover and energetic demands. The vast majority of its energy is produced and cycled in form of ATP which stems mainly from oxidative phosphorylation occurring at the RESPIRATORY CHAIN in the mitochondria. A part from energy production, the RESPIRATORY CHAIN is also the main source of reactive oxygen species and plays a pivotal role in the regulation of oxidative stress. Dysfunction of the RESPIRATORY CHAIN is therefore found in most common heart conditions. The pathophysiology of MITOCHONDRIAL RESPIRATORY CHAIN dysfunction in hereditary cardiac MITOCHONDRIAL disease, the aging heart, in LV hypertrophy and heart failure, and in ischaemia-reperfusion injury is reviewed. We introduce the practicing clinician to the complex physiology of the RESPIRATORY CHAIN, highlight its impact on common CARDIAC DISORDERS and review translational pharmacological and non-pharmacological treatment strategies.

Cites

Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver

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APA: Copy

HASSANPOUR, SEYYED HOSSEIN, DEHGHANI, MOHAMMAD AMIN, & KARAMI, SEYYEDEH ZEINAB. (2018). STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE). JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 10(1), 1-13. SID. https://sid.ir/paper/314932/en

Vancouver: Copy

HASSANPOUR SEYYED HOSSEIN, DEHGHANI MOHAMMAD AMIN, KARAMI SEYYEDEH ZEINAB. STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE). JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2018;10(1):1-13. Available from: https://sid.ir/paper/314932/en

IEEE: Copy

SEYYED HOSSEIN HASSANPOUR, MOHAMMAD AMIN DEHGHANI, and SEYYEDEH ZEINAB KARAMI, “STUDY OF RESPIRATORY CHAIN DYSFUNCTION IN HEART DISEASE (REVIEW ARTICLE),” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 10, no. 1, pp. 1–13, 2018, [Online]. Available: https://sid.ir/paper/314932/en

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