FOSFOMYCIN, INTERESTING ALTERNATIVE DRUG FOR TREATMENT OF URINARY TRACT INFECTIONS CREATED BY MULTIPLE DRUG RESISTANT AND EXTENDED SPECTRUM β-LACTAMASE PRODUCING STRAINS

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YEGANEH SEFIDAN FATEMEH; GHOTASLOU REZA; AKHI MOHAMMAD TAGHI; SADEGHI MOHAMMAD REZA; MOHAMMADZADEH ASL YALDA; BANNAZADEH BAGHI HUSSEIN

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Journal: IRANIAN JOURNAL OF MICROBIOLOGY Year:2016 | Volume:8 | Issue:2 Page(s): 125-131

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Title

FOSFOMYCIN, INTERESTING ALTERNATIVE DRUG FOR TREATMENT OF URINARY TRACT INFECTIONS CREATED BY MULTIPLE DRUG RESISTANT AND EXTENDED SPECTRUM β-LACTAMASE PRODUCING STRAINS

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Keywords

ENTEROBACTERIACEAE

ESBL

FOSFOMYCIN

MDR

UTIS

Abstract

Background and Objectives: The emergence and spread of multidrug resistant (MDR) and extended spectrum b-lactamase (ESBL) producing strains reduces the number of effective drugs that can be used for treatment. The aim of this study was to evaluate the susceptibility profile of Enterobacteriaceae isolated from UTIs, specifically MDR and ESBL producing strains, to fosfomycin and other antibiotics.Materials and Methods: The study was performed during a 6 month period (February 2014 to August 2015). A total of 219 non-duplicate urinary isolates of Enterobacteriaceae were collected. Identification and susceptibility testing was done according to standard microbiological procedures and the Kirby- Bauer test, respectively. Based on the results obtained from susceptibility testing, MDR bacteria were recovered and identification of ESBL production was done according to CLSI recommendation.Results: Isolates of E. coli and Klebsiella spp. were responsible for 80.8% and 12.8% of patients with UTIs respectively. The rates of resistance to ampicillin, cefazolin, nalidixic acid, trimethoprim-sulfamethoxazole were 86.3%, 79.4%, 68.5% and 63.9% respectively. In contrast, high sensitivity rates were detected to fosfomycin, amikacin and amoxicillin-clavulanic acid with 97.3%, 91.8% and 80.8%, respectively. Of all isolates, 167 (76.3%) were detected as MDR and 75 (34.2%) as ESBL producing strains.Conclusion: The rate of antibiotic resistance among uropathogens Enterobacteriaceae is remarkably high. The most effective antibiotic was fosfomycin. Moreover, susceptibility to fosfomycin is over 90% for MDR and ESBL producer isolates. Therefore, fosfomycin can be a good option for treating UTIs.

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APA: Copy

YEGANEH SEFIDAN, FATEMEH, GHOTASLOU, REZA, AKHI, MOHAMMAD TAGHI, SADEGHI, MOHAMMAD REZA, MOHAMMADZADEH ASL, YALDA, & BANNAZADEH BAGHI, HUSSEIN. (2016). FOSFOMYCIN, INTERESTING ALTERNATIVE DRUG FOR TREATMENT OF URINARY TRACT INFECTIONS CREATED BY MULTIPLE DRUG RESISTANT AND EXTENDED SPECTRUM β-LACTAMASE PRODUCING STRAINS. IRANIAN JOURNAL OF MICROBIOLOGY, 8(2), 125-131. SID. https://sid.ir/paper/315374/en

Vancouver: Copy

YEGANEH SEFIDAN FATEMEH, GHOTASLOU REZA, AKHI MOHAMMAD TAGHI, SADEGHI MOHAMMAD REZA, MOHAMMADZADEH ASL YALDA, BANNAZADEH BAGHI HUSSEIN. FOSFOMYCIN, INTERESTING ALTERNATIVE DRUG FOR TREATMENT OF URINARY TRACT INFECTIONS CREATED BY MULTIPLE DRUG RESISTANT AND EXTENDED SPECTRUM β-LACTAMASE PRODUCING STRAINS. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2016;8(2):125-131. Available from: https://sid.ir/paper/315374/en

IEEE: Copy

FATEMEH YEGANEH SEFIDAN, REZA GHOTASLOU, MOHAMMAD TAGHI AKHI, MOHAMMAD REZA SADEGHI, YALDA MOHAMMADZADEH ASL, and HUSSEIN BANNAZADEH BAGHI, “FOSFOMYCIN, INTERESTING ALTERNATIVE DRUG FOR TREATMENT OF URINARY TRACT INFECTIONS CREATED BY MULTIPLE DRUG RESISTANT AND EXTENDED SPECTRUM β-LACTAMASE PRODUCING STRAINS,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 8, no. 2, pp. 125–131, 2016, [Online]. Available: https://sid.ir/paper/315374/en

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