ALLELIC FORMS OF MEROZOITE SURFACE PROTEIN-3 IN PLASMODIUM FALCIPARUM ISOLATES FROM SOUTHEAST OF IRAN

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EBRAHIMZADEH ADEL; MOHAMMADI SAEED; JAMSHIDI ALI

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Journal Paper

Paper Information

Journal: Jundishapur Journal of Microbiology Year:2014 | Volume:7 | Issue:5 Page(s): 0-0

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Title

ALLELIC FORMS OF MEROZOITE SURFACE PROTEIN-3 IN PLASMODIUM FALCIPARUM ISOLATES FROM SOUTHEAST OF IRAN

Author(s)

EBRAHIMZADEH ADEL | MOHAMMADI SAEED | JAMSHIDI ALI | Issue Writer Certificate

Keywords

PLASMODIUM FALCIPARUM

MEROZOITE SURFACE PROTEIN 3

PLASMODIUM

GENETIC VARIATION

IRAN

Abstract

Background: Genetic diversity has provided PLASMODIUM FALCIPARUM with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites. Merozoite surface protein-3 (MSP-3) has been used to develop vaccines and investigate the genetic diversity regarding P. falciparum malaria in IRAN.Objectives: The main goal of this study was to analyze the polymorphic antigen MSP-3 genes across southeast of IRAN among four different districts, to identify the differences in the allele frequency and genetic diversity.Materials and Methods: Nested polymerase chain reaction amplification was used to determine polymorphisms of N-terminal region of the MSP-3 gene. A total of 85 microscopically positive P. falciparum infected individuals from southeast of IRAN were included in this study.Results: Of the 85 confirmed P. falciparum samples obtained from four different districts, 72 were successfully scored for MSP-3.The MSP-3 allele classes (K1 and 3D7 types) showed comparable prevalence in all districts. Overall frequencies of K1 and 3D7 allele classes were 94.5 % for both.Conclusions: Since no study has yet looked at the extent of P. falciparum MSP-3 in this geographic region, these data can be helpful to support development of a vaccine based on MSP-3 against malaria. There should be a comparative analysis in different seasonal peaks to indicate the allelic polymorphism of MSP-3 over a period.

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APA: Copy

EBRAHIMZADEH, ADEL, MOHAMMADI, SAEED, & JAMSHIDI, ALI. (2014). ALLELIC FORMS OF MEROZOITE SURFACE PROTEIN-3 IN PLASMODIUM FALCIPARUM ISOLATES FROM SOUTHEAST OF IRAN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(5), 0-0. SID. https://sid.ir/paper/317402/en

Vancouver: Copy

EBRAHIMZADEH ADEL, MOHAMMADI SAEED, JAMSHIDI ALI. ALLELIC FORMS OF MEROZOITE SURFACE PROTEIN-3 IN PLASMODIUM FALCIPARUM ISOLATES FROM SOUTHEAST OF IRAN. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2014;7(5):0-0. Available from: https://sid.ir/paper/317402/en

IEEE: Copy

ADEL EBRAHIMZADEH, SAEED MOHAMMADI, and ALI JAMSHIDI, “ALLELIC FORMS OF MEROZOITE SURFACE PROTEIN-3 IN PLASMODIUM FALCIPARUM ISOLATES FROM SOUTHEAST OF IRAN,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 7, no. 5, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/317402/en

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