مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ANALYSIS OF HEALING EFFECT OF ALGINATE SULFATE HYDROGEL DRESSING CONTAINING ANTIMICROBIAL PEPTIDE ON WOUND INFECTION CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

Pages

  1-7

Abstract

 Background: WOUND INFECTIONs caused by methicillin-resistant STAPHYLOCOCCUS AUREUS are a health problem worldwide; therefore, it is necessary to develop new antimicrobial compounds. Considering broad-spectrum antimicrobial activity and low probability of drug resistance to peptides, applications these peptides are being studied extensively.Objectives: In this study, to control drug release over time, an ALGINATE sulfate-based HYDROGEL impregnated with the CM11 peptide as the antimicrobial agent was developed, and its healing effects were tested on skin infections caused by methicillin-resistant S. aureus strains in a mouse model.Materials and Methods: Minimum inhibitory and minimum bactericidal concentrations of the CM11 peptide and ALGINATE HYDROGEL in combination with the peptide were determined. Forty mice were divided into 4 groups: 1 group as a negative control (without treatment; however, 5 mice received HYDROGEL dressing without peptide), 1 group as a positive control (2% mupirocin treatment), and 2 groups as test groups. To establish skin infection, 200 mL of bacterial suspension with 3×108 CFU/mL concentration was subcutaneously injected in the scapular region of the mice. On the basis of the in vitro minimal bactericidal concentration of the ALGINATE HYDROGEL containing peptide for 15 clinical isolates, HYDROGEL containing 128 mg/L of peptide was used for wound dressing over an 8-day period.Results: The highest and lowest numbers of wounds were observed on day 2 in the negative and positive control groups, respectively. During the 8-day period, the positive control and HYDROGEL containing peptide treatment groups showed similar levels of wound healing.Conclusions: This study showed that compared to standard drug treatment, treatment with HYDROGEL containing peptide had substantial antibacterial effects on S. aureus WOUND INFECTIONs in mice.

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    APA: Copy

    BABAVALIAN, HAMID, LATIFI, ALI MOHAMMAD, SHOKRGOZAR, MOHAMMAD ALI, BONAKDAR, SHAHIN, MOHAMMADI, SAJJAD, & MOOSAZADEH MOGHADDAM, MEHRDAD. (2015). ANALYSIS OF HEALING EFFECT OF ALGINATE SULFATE HYDROGEL DRESSING CONTAINING ANTIMICROBIAL PEPTIDE ON WOUND INFECTION CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(9), 1-7. SID. https://sid.ir/paper/317473/en

    Vancouver: Copy

    BABAVALIAN HAMID, LATIFI ALI MOHAMMAD, SHOKRGOZAR MOHAMMAD ALI, BONAKDAR SHAHIN, MOHAMMADI SAJJAD, MOOSAZADEH MOGHADDAM MEHRDAD. ANALYSIS OF HEALING EFFECT OF ALGINATE SULFATE HYDROGEL DRESSING CONTAINING ANTIMICROBIAL PEPTIDE ON WOUND INFECTION CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(9):1-7. Available from: https://sid.ir/paper/317473/en

    IEEE: Copy

    HAMID BABAVALIAN, ALI MOHAMMAD LATIFI, MOHAMMAD ALI SHOKRGOZAR, SHAHIN BONAKDAR, SAJJAD MOHAMMADI, and MEHRDAD MOOSAZADEH MOGHADDAM, “ANALYSIS OF HEALING EFFECT OF ALGINATE SULFATE HYDROGEL DRESSING CONTAINING ANTIMICROBIAL PEPTIDE ON WOUND INFECTION CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 9, pp. 1–7, 2015, [Online]. Available: https://sid.ir/paper/317473/en

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