LAMIVUDINE RESISTANCE AND PRECORE VARIANTS IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS B: CORRELATION WITH VIROLOGICAL AND CLINICAL FEATURES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POORTAHMASEBI VAHDAT; MALEKZADEH REZA; MONTAZERI GHODRATOLLAH; FAKHARI EHSAN; NOROUZI MEHDI; KHAMSEH AZAM; MAHMOODI KARKHANEH MASOUD; TAVAKOLI AHMAD; JAZAYERI SEYED MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jundishapur Journal of Microbiology Year:2015 | Volume:8 | Issue:9 Page(s): 1-5

Download Full-Text

View:

332

Download:

140

Cites:

Information Journal Paper

Title

LAMIVUDINE RESISTANCE AND PRECORE VARIANTS IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS B: CORRELATION WITH VIROLOGICAL AND CLINICAL FEATURES

Author(s)

Keywords

THERAPY

LAMIVUDINE

MUTATIONS

Abstract

Background: Long-term LAMIVUDINE THERAPY, despite its initial effectiveness against hepatitis B virus (HBV), is associated with the emergence of drug resistance MUTATIONS in polymerase protein.Objectives: The aim of the present study was to determine the prevalence of precore and LAMIVUDINE drug resistance MUTATIONS in LAMIVUDINE treated patients with chronic B hepatitis.Patients and Methods: Sequential sera were obtained from 88 chronic HBV carriers who received LAMIVUDINE for more than 24 months. Polymerase and precore regions were directly sequenced for these groups: I (before treatment), II, and III (12 and 24 months after treatment, respectively).Results: All patients (100%) were contained genotype D, subtype ayw2. One (1.1%), 12 (13.6%), and 22 (25%) members of groups I, II, and III had the replacement of either isoleucine or valine instead of methionine in tyrosine-methionine-aspartate-aspartate (YMDD) motif, respectively. The frequency of MUTATIONS from 0 time point to 12 and 24 months showed that there was an increasing trend between sequential samples (P<0.001). In group I, 31 (35.2%); II, 36 (41.0%) and III, 41 (46.6%) members had the precore stop codon MUTATIONS. The frequency of MUTATIONS from 0 time point to 12 and 24 months showed that there was an ascending trend between sequential samples. Indeed, frequency of precore stop codon was significantly increased with the passage of time (P<0.001).Conclusions: Presence of drug resistance MUTATIONS among the patients was significant. Precore MUTATIONS were common amongst Iranian HBV chronic carriers under LAMIVUDINE THERAPY and these MUTATIONS were accompanied by clinical relapse.

Cites

No record.

References

Cite

APA: Copy

POORTAHMASEBI, VAHDAT, MALEKZADEH, REZA, MONTAZERI, GHODRATOLLAH, FAKHARI, EHSAN, NOROUZI, MEHDI, KHAMSEH, AZAM, MAHMOODI KARKHANEH, MASOUD, TAVAKOLI, AHMAD, & JAZAYERI, SEYED MOHAMMAD. (2015). LAMIVUDINE RESISTANCE AND PRECORE VARIANTS IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS B: CORRELATION WITH VIROLOGICAL AND CLINICAL FEATURES. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(9), 1-5. SID. https://sid.ir/paper/317482/en

Vancouver: Copy

POORTAHMASEBI VAHDAT, MALEKZADEH REZA, MONTAZERI GHODRATOLLAH, FAKHARI EHSAN, NOROUZI MEHDI, KHAMSEH AZAM, MAHMOODI KARKHANEH MASOUD, TAVAKOLI AHMAD, JAZAYERI SEYED MOHAMMAD. LAMIVUDINE RESISTANCE AND PRECORE VARIANTS IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS B: CORRELATION WITH VIROLOGICAL AND CLINICAL FEATURES. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(9):1-5. Available from: https://sid.ir/paper/317482/en

IEEE: Copy

VAHDAT POORTAHMASEBI, REZA MALEKZADEH, GHODRATOLLAH MONTAZERI, EHSAN FAKHARI, MEHDI NOROUZI, AZAM KHAMSEH, MASOUD MAHMOODI KARKHANEH, AHMAD TAVAKOLI, and SEYED MOHAMMAD JAZAYERI, “LAMIVUDINE RESISTANCE AND PRECORE VARIANTS IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS B: CORRELATION WITH VIROLOGICAL AND CLINICAL FEATURES,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 9, pp. 1–5, 2015, [Online]. Available: https://sid.ir/paper/317482/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops