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Information Journal Paper

Title

PREVALENCE OF INFLUENZA A(H1N1) PDM09 VIRUS RESISTANT TO OSELTAMIVIR IN SHIRAZ, IRAN, DURING 2012- 2013

Pages

  1-6

Keywords

INFLUENZA A(H1N1) VIRUS 

Abstract

 Background: OSELTAMIVIR has been used as a drug of choice for the prophylaxis and treatment of human influenza A(H1N1) pdm09 infection across the world. However, the most frequently identified OSELTAMIVIR resistant virus, influenza A(H1N1) pdm09, exhibit the H275Y substitution in NA gene.Objectives: This study aimed to determine the prevalence and phylogenetic relationships of OSELTAMIVIR resistance in influenza A(H1N1) pdm09 viruses isolated in Shiraz, IRAN.Patients and Methods: Throat swab samples were collected from 200 patients with influenza-like disease from December 2012 until February 2013. A total of 77 influenza A(H1N1) pdm09 positive strains were identified by real-time polymerase chain reaction (PCR). OSELTAMIVIR resistance was detected using quantal assay and nested-PCR method. The NA gene sequencing was conducted to detect OSELTAMIVIR-resistant mutants and establish the phylogeny of the prevalent influenza variants.Results: Our results revealed that A(H1N1) pdm09 viruses present in these samples were susceptible to OSELTAMIVIR, and contained 5 site specific mutations (V13G, V106I, V241I, N248D, and N369K) in NA gene. These mutations correlated with increasing expression and enzymatic activity of NA protein in the influenza A(H1N1) pdm09 viruses, which were closely related to a main influenza A(H1N1) pdm09 cluster isolated around the world.Conclusions: A(H1N1)pdm09 viruses, identified in this study in Shiraz, IRAN, contained 5 site specific mutations and were susceptible to OSELTAMIVIR.

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    APA: Copy

    KHODADAD, NASTARAN, MOATTARI, AFAGH, SHAMSI SHAHRABADI, MAHMOUD, KADIVAR, MOHAMMAD RAHIM, SARVARI, JAMAL, TAVAKOLI, FOROUGH, PIRBONYEH, NEDA, & EMAMI, AMIR. (2015). PREVALENCE OF INFLUENZA A(H1N1) PDM09 VIRUS RESISTANT TO OSELTAMIVIR IN SHIRAZ, IRAN, DURING 2012- 2013. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(8), 1-6. SID. https://sid.ir/paper/317495/en

    Vancouver: Copy

    KHODADAD NASTARAN, MOATTARI AFAGH, SHAMSI SHAHRABADI MAHMOUD, KADIVAR MOHAMMAD RAHIM, SARVARI JAMAL, TAVAKOLI FOROUGH, PIRBONYEH NEDA, EMAMI AMIR. PREVALENCE OF INFLUENZA A(H1N1) PDM09 VIRUS RESISTANT TO OSELTAMIVIR IN SHIRAZ, IRAN, DURING 2012- 2013. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(8):1-6. Available from: https://sid.ir/paper/317495/en

    IEEE: Copy

    NASTARAN KHODADAD, AFAGH MOATTARI, MAHMOUD SHAMSI SHAHRABADI, MOHAMMAD RAHIM KADIVAR, JAMAL SARVARI, FOROUGH TAVAKOLI, NEDA PIRBONYEH, and AMIR EMAMI, “PREVALENCE OF INFLUENZA A(H1N1) PDM09 VIRUS RESISTANT TO OSELTAMIVIR IN SHIRAZ, IRAN, DURING 2012- 2013,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 8, pp. 1–6, 2015, [Online]. Available: https://sid.ir/paper/317495/en

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