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Information Journal Paper

Title

PROTEIN-PROTEIN INTERACTION NETWORK COULD REVEAL THE RELATIONSHIP BETWEEN THE BREAST AND COLON CANCER

Pages

  215-224

Abstract

 Aim: This study is aimed to elicit the possible correlation between breast and COLON CANCER from molecular prospective by analyzing and comparing pathway-based biomarkers.Background: Breast and COLON CANCER are known to be frequent causes of morbidity and mortality in men and women around the world. There is some evidence that while the incident of BREAST CANCER in young women is high, it is reported lower in the aged women. In fact, aged women are more prone to colorectal cancer than older men. In addition, many studies showed that several biomarkers are common among these malignancies.Patients and methods: The genes were retrieved and compared from KEGG database and WikiPathway, and subsequently, protein-protein interaction (PPI) network was constructed and analyzed using Cytoscape v: 3.2.1 software and related algorithms.Results: More than forty common genes were identified among these malignancies; however, by pathways comparison, twenty genes are related to both breast and COLON CANCER. Centrality and cluster screening identified hub genes, including SMAD2, SMAD3, (SMAD4, MYC), JUN, BAD, TP53. These seven genes are enriched in regulation of transforming growth factor beta receptor signaling pathway, positive regulation of Rac protein signal transduction, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, and positive regulation of mitotic metaphase/anaphase transition respectively.Conclusion: As there are numerous genes frequent between colorectal cancer and BREAST CANCER, there may be a common molecular origin for these malignancies occurrences. It seems that BREAST CANCER in females interferes with the rate of colorectal cancer incidence.

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    APA: Copy

    ZAMANIAN AZODI, MONA, REZAEI TAVIRANI, MOSTAFA, RAHMATIRAD, SARA, HASANZADEH, HADI, REZAEI TAVIRANI, MAJID, & SEYYEDI, SAMANEH SADAT. (2015). PROTEIN-PROTEIN INTERACTION NETWORK COULD REVEAL THE RELATIONSHIP BETWEEN THE BREAST AND COLON CANCER. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(3), 215-224. SID. https://sid.ir/paper/324655/en

    Vancouver: Copy

    ZAMANIAN AZODI MONA, REZAEI TAVIRANI MOSTAFA, RAHMATIRAD SARA, HASANZADEH HADI, REZAEI TAVIRANI MAJID, SEYYEDI SAMANEH SADAT. PROTEIN-PROTEIN INTERACTION NETWORK COULD REVEAL THE RELATIONSHIP BETWEEN THE BREAST AND COLON CANCER. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(3):215-224. Available from: https://sid.ir/paper/324655/en

    IEEE: Copy

    MONA ZAMANIAN AZODI, MOSTAFA REZAEI TAVIRANI, SARA RAHMATIRAD, HADI HASANZADEH, MAJID REZAEI TAVIRANI, and SAMANEH SADAT SEYYEDI, “PROTEIN-PROTEIN INTERACTION NETWORK COULD REVEAL THE RELATIONSHIP BETWEEN THE BREAST AND COLON CANCER,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 3, pp. 215–224, 2015, [Online]. Available: https://sid.ir/paper/324655/en

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