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Cites:

1

Information Journal Paper

Title

Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis

Pages

  319-324

Abstract

 Aim: To investigate whether Aggressive hydration can increase the efficacy of prophylactic non-steroid anti-inflammatory drugs (NSAIDs) in Prevention of post-ERCP Pancreatitis. Background: NSAIDs are recommended for the Prevention of PEP; however, whether Aggressive hydration can have additional benefits in this regard is not known. Methods: Patients candidate for ERCP received either pre-procedural rectal Diclofenac (100 mg) alone (n = 112) or in combination with Aggressive hydration by lactate ringer’ s (n = 107) as prophylactic method. PEP was defined based on increase in serum levels of pancreatic enzymes (from baseline to 24 hours following the procedure) accompanied with symptoms. Results: PEP was occurred in 3 patients in the Diclofenac only group and in 1 patient in the Diclofenac + hydration group with no significant difference (2. 7% vs. 0. 9%, P = 0. 622). Serum amylase levels decreased over time in the Diclofenac + hydration group but not in the Diclofenac only group. Also, serum lipase levels decreased more rapidly over time in the Diclofenac + hydration group compared to the Diclofenac only group. Conclusion: Combination prophylactic therapy with NSAIDs plus Aggressive hydration does not seem to have additional clinically important benefits in preventing PEP. Studies with larger sample of patients are required in this regard.

Cites

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    APA: Copy

    Hajalikhani, Mehri, EMAMI, MOHAMMAD HASSAN, KHODADOOSTAN, MAHSA, SHAVAKHI, AHMAD, Rezaei, Moein, & Soluki, Reza. (2018). Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(4), 319-324. SID. https://sid.ir/paper/324799/en

    Vancouver: Copy

    Hajalikhani Mehri, EMAMI MOHAMMAD HASSAN, KHODADOOSTAN MAHSA, SHAVAKHI AHMAD, Rezaei Moein, Soluki Reza. Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(4):319-324. Available from: https://sid.ir/paper/324799/en

    IEEE: Copy

    Mehri Hajalikhani, MOHAMMAD HASSAN EMAMI, MAHSA KHODADOOSTAN, AHMAD SHAVAKHI, Moein Rezaei, and Reza Soluki, “Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. 4, pp. 319–324, 2018, [Online]. Available: https://sid.ir/paper/324799/en

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