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Information Journal Paper

Title

ANTICONVULSANT EFFECT OF SATUREJA HORTENSIS AERIAL PARTS EXTRACTS IN MICE

Pages

  305-312

Abstract

 Objective: Regarding the anticonvulsant effects of SATUREJA HORTENSIS (S. hortensis) in Avicenna’s book: canon of medicine; the present study was undertaken to evaluate the anti- eplileptic effects of S. hortensis aqueous and ethanolic aerial part extracts. Furthermore, the mechanisms of their anticonvulsant activities were also evaluated.Materials and Methods: SEIZURE was induced by Pentylentetrazol (PTZ) and MES (maximal electroshock) models. Mice were randomly divided into 8 groups; negative control (normal saline, 10ml/Kg), positive control (diazepam, 2 mg/kg), S. hortensis aqueous and ethanolic extracts (200, 400 and 600 mg/kg). In PTZ test, latency to the first minimal clonic SEIZURE (MCS), latency to the first generalized tonic–clonic SEIZUREs (GTCS), the total duration of SEIZUREs and protection against mortality were evaluated. In MES test, the stretching length of extremities and protection against mortality were recorded.Results: Aqueous and ethanolic extracts (400 and 600 mg/kg) significantly increased MCS and GTCS latencies in PTZ model. Three doses of the extracts decreased the total duration of SEIZURE. These extracts did not show any protective effects on SEIZURE induced by MES model. In PTZ model, FLUMAZENIL, an antagonist of benzodiazepine (BZD) site in the GABAA-BZD receptor complex and 7- nitroindazole (7- NI), a selective nNOS (neuronal nitric oxide synthase) inhibitor, reduced the prolongation of SEIZURE latency.Conclusion: S. hortensis showed anticonvulsant activity in PTZ model and this effect may be mediated, at least partly, through interacting with nitric oxide and GABAA-BZD receptor complex.

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    Cite

    APA: Copy

    ZOLFAGHARIAN, FARZANEH, RAZAVI, BIBI MARJAN, & HOSSEINZADEH, HOSSEIN. (2016). ANTICONVULSANT EFFECT OF SATUREJA HORTENSIS AERIAL PARTS EXTRACTS IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(3), 305-312. SID. https://sid.ir/paper/326328/en

    Vancouver: Copy

    ZOLFAGHARIAN FARZANEH, RAZAVI BIBI MARJAN, HOSSEINZADEH HOSSEIN. ANTICONVULSANT EFFECT OF SATUREJA HORTENSIS AERIAL PARTS EXTRACTS IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(3):305-312. Available from: https://sid.ir/paper/326328/en

    IEEE: Copy

    FARZANEH ZOLFAGHARIAN, BIBI MARJAN RAZAVI, and HOSSEIN HOSSEINZADEH, “ANTICONVULSANT EFFECT OF SATUREJA HORTENSIS AERIAL PARTS EXTRACTS IN MICE,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 3, pp. 305–312, 2016, [Online]. Available: https://sid.ir/paper/326328/en

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