Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis

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Barkhidarian Bahareh; khorshidi Masoud; SHAB BIDAR SAKINEH; HASHEMI BARAN

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Journal Paper

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Journal: Avicenna Journal of Phytomedicine Year:2019 | Volume:9 | Issue:1 Page(s): 10-20

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Title

Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis

Author(s)

Barkhidarian Bahareh | khorshidi Masoud | SHAB BIDAR SAKINEH | HASHEMI BARAN | Issue Writer Certificate

Keywords

L-citrulline

Blood pressure

Supplementation

Abstract

Objective: We aimed to conduct a systematic review and metaanalysis of clinical trials that examined the effects of L-citrulline Supplementation on Blood pressure (BP). Materials and Methods: We searched MEDLINE, SCOPUS, PUBMED and Google scholar databases from inception to November 16, 2017 and 811 papers were identified, of which 8 trials with 10 data sets met the inclusion criteria. Inclusion criteria were: (1) application of randomized clinical trial with either crossover or parallel designs; (2) studies conducted in adults (≥ 18 y); (3) oral Supplementation with L-citrulline compared to control group; (4) expression of sufficient data about systolic and diastolic BP at baseline and at the end of the study in each group. BP effects were pooled by random-effects models, with trials weighted by inverse variance. Results: The included studies’ sample size ranged between 12 and 34 subjects. The mean age of the participants in these trials ranged between 22 and 71 years. Dosage of L-citrulline Supplementation varied from 3 to 9 g/day. Duration of the intervention ranged between 1 and 17 weeks. The pooled changes in systolic and diastolic BP were (MD, − 4. 10 mm Hg; 95% CI [− 7. 94,-0. 26]; p=0. 037) and (MD − 2. 08 mm Hg; 95% CI [− 4. 32, 0. 16]; P=0. 069), respectively. The subgroup analysis showed a significant diastolic BP reduction in studies that used doses of ≥ 6 g/day (MD − 2. 75 mm Hg; 95% CI [− 5. 37,-0. 12]; p=0. 04). Conclusion: Our results suggest that L-citrulline Supplementation may reduce systolic BP. A significant reduction in diastolic BP was observed only in the studies that used doses ≥ 6 g/day.

Cites

The Effect of Resistance Training Program with Citrulline-Malate on Blood Pressure, Nitric Oxide, and Vascular Endothelial Growth Factor in Postmenopausal Women with Prehypertension

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APA: Copy

Barkhidarian, Bahareh, khorshidi, Masoud, SHAB BIDAR, SAKINEH, & HASHEMI, BARAN. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(1), 10-20. SID. https://sid.ir/paper/326498/en

Vancouver: Copy

Barkhidarian Bahareh, khorshidi Masoud, SHAB BIDAR SAKINEH, HASHEMI BARAN. Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(1):10-20. Available from: https://sid.ir/paper/326498/en

IEEE: Copy

Bahareh Barkhidarian, Masoud khorshidi, SAKINEH SHAB BIDAR, and BARAN HASHEMI, “Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 1, pp. 10–20, 2019, [Online]. Available: https://sid.ir/paper/326498/en

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