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Information Journal Paper

Title

Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats

Pages

  597-605

Abstract

 Objective: In the present study, we aimed to examine the effect of Troxerutin treatment on levels of brain-derived neurotrophic factor (BDNF), and tumor necrosis factor-alpha (TNF-α ) and interleukin6 (IL-6), as pro-Inflammatory cytokines, in the blood and hippocampus of high-fat diet (HFD) fed dams and their male offspring. Materials and Methods: Forty virgin female Wistar rats, 3 weeks old, were divided into two groups (n=20/per group) and fed control diet (CD), or HFD for 8 weeks. After mating, pregnant animals were assigned to four subgroups including: control (CD), control+Troxerutin (CD+T), high-fat diet (HFD), and HFD+Troxerutin (HFD+T) groups. HFD was continued during pregnancy and lactation. Troxerutin (150 mg/kg/day, P. O. ) was administered during pregnancy in the CD+T and HFD+T groups. On postnatal day (PND) 21, male offspring were separated and fed a normal diet until PND 90. Inflammatory cytokines (TNF-α , and IL-6) and BDNF levels were measured in the serum and hippocampal samples using rat-specific enzyme-linked immunosorbent assay (ELISA) kits. Results: Our findings showed a significant increase in the serum levels of TNF-α and IL-6, but a decrease in BDNF levels in the serum of HFD-fed dams in comparison with CD group, which was reversed by Troxerutin. Moreover, Troxerutin treatment, during pregnancy, significantly decreased TNF-α and IL-6 levels, but increased BDNF level in the serum and hippocampus of HFD+T offspring in comparison with HFD offspring. Conclusion: These results showed that Troxerutin could prevent the harmful effects of maternal HFD on their offspring through inhibition of pro-Inflammatory cytokines and elevation of BDNF levels.

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    APA: Copy

    Hosseindoost, Maryam, ALIPOUR, MOHAMMAD REZA, Farajdokht, Fereshteh, Diba, Roghayeh, Bayandor, Parvin, Mehri, Keyvan, Nayebi Rad, Sepehr, & BABRI, SHIRIN. (2019). Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(6), 597-605. SID. https://sid.ir/paper/326542/en

    Vancouver: Copy

    Hosseindoost Maryam, ALIPOUR MOHAMMAD REZA, Farajdokht Fereshteh, Diba Roghayeh, Bayandor Parvin, Mehri Keyvan, Nayebi Rad Sepehr, BABRI SHIRIN. Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(6):597-605. Available from: https://sid.ir/paper/326542/en

    IEEE: Copy

    Maryam Hosseindoost, MOHAMMAD REZA ALIPOUR, Fereshteh Farajdokht, Roghayeh Diba, Parvin Bayandor, Keyvan Mehri, Sepehr Nayebi Rad, and SHIRIN BABRI, “Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 6, pp. 597–605, 2019, [Online]. Available: https://sid.ir/paper/326542/en

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