NATURAL KILLER CELL SUBSETS AND IL-2, IL-15, AND IL- 18 GENES EXPRESSIONS IN CHRONIC KIDNEY ALLOGRAFT DYSFUNCTION AND GRAFT FUNCTION IN KIDNEY ALLOGRAFT RECIPIENTS

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ASSADIASL S.; SEPANJNIA A.; AGHILI B.; NAFAR M.; AHMADPOOR P.; POURREZAGHOLI F.; PARVIN M.; SHAHLAEE A.; NICKNAM M.H.; AMIRZARGAR A.

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Journal: INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE Year:2016 | Volume:7 | Issue:4 Page(s): 212-217

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Title

NATURAL KILLER CELL SUBSETS AND IL-2, IL-15, AND IL- 18 GENES EXPRESSIONS IN CHRONIC KIDNEY ALLOGRAFT DYSFUNCTION AND GRAFT FUNCTION IN KIDNEY ALLOGRAFT RECIPIENTS

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Keywords

CHRONIC ALLOGRAFT DYSFUNCTION

NATURAL KILLER CELLS

INTERLEUKIN GENE EXPRESSION

Abstract

Background: While acute rejection and early graft loss rates have decreased substantially over the past four decades, progressive chronic allograft dysfunction (CAD) still remains a common cause of late graft loss in kidney transplant recipients.Objective: This study was conducted to investigate the percentage of natural killer (NK) cell subsets and IL-2, 15 and 18 genes expression in two groups of CAD and well-function graft (WFG) recipients.Methods: 30 renal allograft recipients with biopsy-proven interstitial fibrosis/tubular atrophy (IF/TA) and impaired renal function, and 30 sex- and age-matched WFG patients were enrolled in this study. The percentage of NK cell subsets including NK CD56bright and NK CD56dim cells were determined by flowcytometry, IL-2, IL-15, and IL-18 genes expressions were assessed by real-time PCR.Results: Compared to WFG patients, there was a significant (p<0.05) increase in the percentage of NK CD56bright cells in CAD patients. However, the difference in percentage of NK CD56dim cells or CD56dim/ CD56bright ratio between the studied groups was not significant. In addition, IL-2, 15 and 18 genes expressions were almost similar in CAD and WFG patients.Conclusion: We found higher percentages of NK CD56bright subset in kidney transplant recipients with CAD without considerable changes in related cytokines’ gene expression, suggesting a possible defect of NK cells maturation in these patients.

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APA: Copy

ASSADIASL, S., SEPANJNIA, A., AGHILI, B., NAFAR, M., AHMADPOOR, P., POURREZAGHOLI, F., PARVIN, M., SHAHLAEE, A., NICKNAM, M.H., & AMIRZARGAR, A.. (2016). NATURAL KILLER CELL SUBSETS AND IL-2, IL-15, AND IL- 18 GENES EXPRESSIONS IN CHRONIC KIDNEY ALLOGRAFT DYSFUNCTION AND GRAFT FUNCTION IN KIDNEY ALLOGRAFT RECIPIENTS. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, 7(4), 212-217. SID. https://sid.ir/paper/327627/en

Vancouver: Copy

ASSADIASL S., SEPANJNIA A., AGHILI B., NAFAR M., AHMADPOOR P., POURREZAGHOLI F., PARVIN M., SHAHLAEE A., NICKNAM M.H., AMIRZARGAR A.. NATURAL KILLER CELL SUBSETS AND IL-2, IL-15, AND IL- 18 GENES EXPRESSIONS IN CHRONIC KIDNEY ALLOGRAFT DYSFUNCTION AND GRAFT FUNCTION IN KIDNEY ALLOGRAFT RECIPIENTS. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE[Internet]. 2016;7(4):212-217. Available from: https://sid.ir/paper/327627/en

IEEE: Copy

S. ASSADIASL, A. SEPANJNIA, B. AGHILI, M. NAFAR, P. AHMADPOOR, F. POURREZAGHOLI, M. PARVIN, A. SHAHLAEE, M.H. NICKNAM, and A. AMIRZARGAR, “NATURAL KILLER CELL SUBSETS AND IL-2, IL-15, AND IL- 18 GENES EXPRESSIONS IN CHRONIC KIDNEY ALLOGRAFT DYSFUNCTION AND GRAFT FUNCTION IN KIDNEY ALLOGRAFT RECIPIENTS,” INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, vol. 7, no. 4, pp. 212–217, 2016, [Online]. Available: https://sid.ir/paper/327627/en

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