DUAL EFFECTS OF TOPIRAMATE ON TOLERANCE TO MORPHINE-INDUCED LOCOMOTORS ACTIVITY IN SMALL LABORATORY MALE MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAVADZADEH SH.; SAHRAEI HEDAYAT; KHOSRAVI MARYAM; GHOSHOUNI H.; FATEMI SEYEDEH MAEDEH; SHAMS J.; NOUROUZZADEH ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2009 | Volume:13 | Issue:4 Page(s): 267-273

Download Full-Text

Persian Verion

View:

828

Download:

Cites:

Information Journal Paper

Title

DUAL EFFECTS OF TOPIRAMATE ON TOLERANCE TO MORPHINE-INDUCED LOCOMOTORS ACTIVITY IN SMALL LABORATORY MALE MICE

Author(s)

Keywords

CONDITIONED PLACE PREFERENCEQ4

MORPHINEQ3

TOPIRAMATEQ3

DRUG SENSITIZATIONQ3

SMALL LABORATORY MICEQ3

Abstract

AIMS: TOPIRAMATE is an anti-convulsing drug, which produced its effects via glutamate metabotropic receptors inhibition and/or GABA receptor excitation. Previous studies indicated that both glutamate and GABA systems have a role in MORPHINE tolerance. In the present study, attempts were made to investigate the effects of TOPIRAMATE on the tolerance to MORPHINE-induced locomotors activity in male mice.METHODS: Male N-MARI mice (20-30 g) were used in this study by open field method. In a pilot study, ineffective doses of the drugs were determined. Then the animals became tolerant to MORPHINE (50 mg/kg; Twice a day for three consecutive days) and their locomotors activity were calculated. Different doses of TOPIRAMATE were administered to the animals 30 minutes before each MORPHINE injection during tolerance development or on the test day 30 minutes before the experiments begining.RESULTS: Injection of MORPHINE in order to develop tolerance, abolished the locomotors activity induced by effective dose of MORPHINE. Injection of TOPIRAMATE reduced the acquisition but enhanced the expression of MORPHINE tolerance. TOPIRAMATE by itself reduced the locomotors activity in MORPHINE-nave animals.CONCLUSION: Topirmate administration leads to inhibition of acquisition but exagerates expression of tolerance to MORPHINE-induced locomotors activity in male mice. It may be due to glutamate and/or GABAergic mechanisms. In addition, TOPIRAMATE by itself reduces the locomotors activity in animals.

Cites

No record.

References

No record.

Cite

APA: Copy

SAHRAEI, HEDAYAT, JAVADZADEH, SH., KHOSRAVI, MARYAM, GHOSHOUNI, H., FATEMI, SEYEDEH MAEDEH, SHAMS, J., & NOUROUZZADEH, ALI. (2009). DUAL EFFECTS OF TOPIRAMATE ON TOLERANCE TO MORPHINE-INDUCED LOCOMOTORS ACTIVITY IN SMALL LABORATORY MALE MICE. KOWSAR MEDICAL JOURNAL, 13(4), 267-273. SID. https://sid.ir/paper/32888/en

Vancouver: Copy

SAHRAEI HEDAYAT, JAVADZADEH SH., KHOSRAVI MARYAM, GHOSHOUNI H., FATEMI SEYEDEH MAEDEH, SHAMS J., NOUROUZZADEH ALI. DUAL EFFECTS OF TOPIRAMATE ON TOLERANCE TO MORPHINE-INDUCED LOCOMOTORS ACTIVITY IN SMALL LABORATORY MALE MICE. KOWSAR MEDICAL JOURNAL[Internet]. 2009;13(4):267-273. Available from: https://sid.ir/paper/32888/en

IEEE: Copy

HEDAYAT SAHRAEI, SH. JAVADZADEH, MARYAM KHOSRAVI, H. GHOSHOUNI, SEYEDEH MAEDEH FATEMI, J. SHAMS, and ALI NOUROUZZADEH, “DUAL EFFECTS OF TOPIRAMATE ON TOLERANCE TO MORPHINE-INDUCED LOCOMOTORS ACTIVITY IN SMALL LABORATORY MALE MICE,” KOWSAR MEDICAL JOURNAL, vol. 13, no. 4, pp. 267–273, 2009, [Online]. Available: https://sid.ir/paper/32888/en

Related Journal Papers