COMPARATIVE EVALUATION OF EFFECTIVENESS OF PRESCRIBED ANTI H. PYLORI REGIMENS USING C14 UREA BREATH TEST

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AMINI MOHSEN; MALEKZADEH R.; VAKILI ARSALAN; MASSERAT S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2001 | Volume:6 | Issue:part 2 Page(s): 111-120

Download Full-Text

Persian Verion

View:

786

Download:

Cites:

Information Journal Paper

Title

COMPARATIVE EVALUATION OF EFFECTIVENESS OF PRESCRIBED ANTI H. PYLORI REGIMENS USING C14 UREA BREATH TEST

Author(s)

AMINI MOHSEN | MALEKZADEH R. | VAKILI ARSALAN | MASSERAT S.

Keywords

H PYLORIQ3

ANTIBIOTICSQ3

C14 UREA BREATH TESTQ4

DEUODENAL ULCERQ4

Abstract

Multiple therapeutic combinations have been tested to determine the ideal regimens for
eradication of Helicobacter Pylori as the major factor in peptic ulcer diseases with
different results depending on geographic area. Our aim was to evaluate the
effectiveness of currently prescribed anti H. Pylori regimens in Tehran-Iran. We
enrolled 415 subjects (242 males, 173 females, age 11-82 years) with documented H.
Pylori infection of the stomach from outpatients of the gastroentrology department of
Shariati Hospital. In all patients H. Pylori infection was identified by rapid urease test
and or histology. Patients were then treated by different H. Pylori regimens (Triple or
quadriple) on an intention to treat basis. One to six months after completion of therapy
C14 urea breath test (C14-UBT) was performed for assessment of eradication. Overall
success rate of all regimens were 37%, patient compliance (usage of> 80% drugs) were
satisfactory (94%) and was identical for all regimens. The results of this intention-to
-treat study was comparable with controlled (perprotocol) studies. The regimen
containing amoxicillin + furazolidone was more successful than that of amoxicillin +
metronidazole (83.3% vs 66.2%, P<0.05). Only the regimen containg amoxicillin +
aetronidazole + omeprazole was superior to H2 receptor antagonists (86.6% Vs 66.2%,
P < 0.05). The most successful antibiotic combination was tetracycline + furazolidone
(100% success rate) which warrants more evaluation in a separate study. Successful
eradication rate was identical in groups 1 and 2 evaluated 1-3 months and 3-6 months
after completion of therapy respectively (73.6% vs 71.1%, P>0.05). Conventialy there
was no significant difference between intention-to-treat therapy with reported
preprotocol eradication rate. The best drug regimen in this study was bismuth +
tetracycline + furazolidone + acid secretory inhibitors. Replacement of metronidazole
by furazolidone was effective in improving eradication rate. In assessment of success of
eradication, results of 3 months versus 6 months after therapy were almost similar and
comparable.

Multimedia

No record.

Cites

References

No record.

Cite

APA: Copy

AMINI, MOHSEN, MALEKZADEH, R., VAKILI, ARSALAN, & MASSERAT, S.. (2001). COMPARATIVE EVALUATION OF EFFECTIVENESS OF PRESCRIBED ANTI H. PYLORI REGIMENS USING C14 UREA BREATH TEST. KOWSAR MEDICAL JOURNAL, 6(part 2), 111-120. SID. https://sid.ir/paper/32931/en

Vancouver: Copy

AMINI MOHSEN, MALEKZADEH R., VAKILI ARSALAN, MASSERAT S.. COMPARATIVE EVALUATION OF EFFECTIVENESS OF PRESCRIBED ANTI H. PYLORI REGIMENS USING C14 UREA BREATH TEST. KOWSAR MEDICAL JOURNAL[Internet]. 2001;6(part 2):111-120. Available from: https://sid.ir/paper/32931/en

IEEE: Copy

MOHSEN AMINI, R. MALEKZADEH, ARSALAN VAKILI, and S. MASSERAT, “COMPARATIVE EVALUATION OF EFFECTIVENESS OF PRESCRIBED ANTI H. PYLORI REGIMENS USING C14 UREA BREATH TEST,” KOWSAR MEDICAL JOURNAL, vol. 6, no. part 2, pp. 111–120, 2001, [Online]. Available: https://sid.ir/paper/32931/en

Related Journal Papers