EFFECT OF AMYGDALA ADENOSINE A1 RECEPTORS ON KINDLED SEIZURES IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; POURGHOLAMI M.H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2003 | Volume:7 | Issue:part 4 Page(s): 275-282

Download Full-Text

Persian Verion

View:

791

Download:

Cites:

Information Journal Paper

Title

EFFECT OF AMYGDALA ADENOSINE A1 RECEPTORS ON KINDLED SEIZURES IN RATS

Author(s)

MIRNAJAFIZADEH S.J. | FATH ELAHI Y. | POURGHOLAMI M.H. | Issue Writer Certificate

Keywords

SEIZUREQ3

HIPPOCAMPUSQ3

AMYGDALAQ4

KINDLINGQ3

N6-CYCLOHEXYLADENOSINEQ4

1Q4

3-DIMETHYL-8-CYCLOPENTHYLXANTHINEQ3

Abstract

Epilepsy is a common neural abnormality. Many investigations on the role of antiepileptic agents using experimental model of epilepsy have been done. on the other hand, adenosine is a neuromodulator which exert anti epileptic effects via its A1 receptors. In this study effects of intra AMYGDALA infusion of a selective adenosine A1 receptor agonist (N6-cyclohexyladenosine;CHA) and a selective adenosine A1 receptor antagonist (1,3-dimetyl-8-cyclopenthylxanthine; CPT) on hippocampal kindled SEIZURE were investigated. All animals had a tripolar electrode implanted into the CA1 region of the HIPPOCAMPUS and a guide cannula attached to a monopolar electrode into the amygdala. One week after surgery, the animals were given by electrical stimulation of the CA1 region of the HIPPOCAMPUS to be kindled and prepared for drug injections. The drugs were dissolved in artificial cerebrospinal fluid. Data showed that intra-amygdala injection of CHA (5nM-1mM; 1µ lit/2min) reduced hippocampal secondary afterdischarge duration and AMYGDALA afterdischarge duration significantly. on the other hand intraamygdala infusion of CPT (0.5 and 1µM) had no significant effect on SEIZURE parameters. Also, intra AMYGDALA CPT pretreatment before CHA, inhibited the CHA effects. Therefore, it may be suggested that in hippocampal KINDLING, the AMYGDALA has a relaying role in spreading afterdischarge especially in producing hippocampal reactivity and secondary afterdischarges and the activity of adenosine A1 receptors of the amygdala reduced this.

Cites

No record.

References

No record.

Cite

APA: Copy

MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., & POURGHOLAMI, M.H.. (2003). EFFECT OF AMYGDALA ADENOSINE A1 RECEPTORS ON KINDLED SEIZURES IN RATS. KOWSAR MEDICAL JOURNAL, 7(part 4), 275-282. SID. https://sid.ir/paper/32947/en

Vancouver: Copy

MIRNAJAFIZADEH S.J., FATH ELAHI Y., POURGHOLAMI M.H.. EFFECT OF AMYGDALA ADENOSINE A1 RECEPTORS ON KINDLED SEIZURES IN RATS. KOWSAR MEDICAL JOURNAL[Internet]. 2003;7(part 4):275-282. Available from: https://sid.ir/paper/32947/en

IEEE: Copy

S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, and M.H. POURGHOLAMI, “EFFECT OF AMYGDALA ADENOSINE A1 RECEPTORS ON KINDLED SEIZURES IN RATS,” KOWSAR MEDICAL JOURNAL, vol. 7, no. part 4, pp. 275–282, 2003, [Online]. Available: https://sid.ir/paper/32947/en

Related Journal Papers