THE SYNERGISTIC EFFECT OF CYTOKINES AND VITAMINED3 ON DIFFERENTIATION OF LEUKEMIC CELLS TREATED WITH CYTOTOXIC AGENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZAKER F.; SALEHIAN OMRAN J.; SOLEYMANI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2006 | Volume:11 | Issue:2 Page(s): 135-141

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

989

Download:

Cites:

Information Journal Paper

Title

THE SYNERGISTIC EFFECT OF CYTOKINES AND VITAMINED3 ON DIFFERENTIATION OF LEUKEMIC CELLS TREATED WITH CYTOTOXIC AGENTS

Author(s)

ZAKER F. | SALEHIAN OMRAN J. | SOLEYMANI M. | Issue Writer Certificate

Keywords

ACUTE PROMYELOCYTIC LEUKEMIAQ3

DIFFERENTIATION THERAPYQ3

VD3Q3

CYTOKINSQ3

CYTOTOXIC AGENTSQ3

Abstract

Objective: The Synergistic Effect of Cytokines and VitamineD3 on Differentiation of Leukemic Cells Treated with CYTOTOXIC AGENTS. Material and Methods: The present study is based on a combined differentiation regimn consisting of differentiation agent (VD3), CYTOKINS (INF-γ and GM-CSF) and chemotherapy (Cytosine-arabinoside and vincristin) on HL60 cells as model of acute promyelocytic leukaemia. Counting of cells morphology and peroxidase staining, NBT reduction performed to assess activity of ptoliferation and differentiation of cells after 5 days of induction. Cytofluorescent analysis performed by flow cytometry using CD45, CD14 and CDllb markers. Results: The result showed that at optimal and non toxic concentration of all drugs proliferation cussed alone or in combination with VD3 .The maximal cessation of proliferation was observed by combination of VD3,cytokins and cytotoxic agent (P<0.05). All drugs except vincristine showed differetiation effect .Combination with VD3 resulted differentiation using all drugs (P<0.05).The maximal differentiation was observed in combination of VD3, CYTOKINS with or without CYTOTOXIC AGENTS leading to granulocytic lineage. Conclusions: These data showed that combination of VD3 and CYTOKINS provide promotion of differentiation and combination with optimal concentration of cytotoxic drugs caused maximal effect on proliferation without cessation of differentiation.

Cites

No record.

References

No record.

Cite

APA: Copy

ZAKER, F., SALEHIAN OMRAN, J., & SOLEYMANI, M.. (2006). THE SYNERGISTIC EFFECT OF CYTOKINES AND VITAMINED3 ON DIFFERENTIATION OF LEUKEMIC CELLS TREATED WITH CYTOTOXIC AGENTS. KOWSAR MEDICAL JOURNAL, 11(2), 135-141. SID. https://sid.ir/paper/33037/en

Vancouver: Copy

ZAKER F., SALEHIAN OMRAN J., SOLEYMANI M.. THE SYNERGISTIC EFFECT OF CYTOKINES AND VITAMINED3 ON DIFFERENTIATION OF LEUKEMIC CELLS TREATED WITH CYTOTOXIC AGENTS. KOWSAR MEDICAL JOURNAL[Internet]. 2006;11(2):135-141. Available from: https://sid.ir/paper/33037/en

IEEE: Copy

F. ZAKER, J. SALEHIAN OMRAN, and M. SOLEYMANI, “THE SYNERGISTIC EFFECT OF CYTOKINES AND VITAMINED3 ON DIFFERENTIATION OF LEUKEMIC CELLS TREATED WITH CYTOTOXIC AGENTS,” KOWSAR MEDICAL JOURNAL, vol. 11, no. 2, pp. 135–141, 2006, [Online]. Available: https://sid.ir/paper/33037/en

Related Journal Papers