SYNERGISTIC EFFECT OF Γ-INTERFERON AND ERYTHROPOIETIN ON DIFFERENTIATION OF
K562 CELL LINE TREATED WITH CYTOTOXIC DRUGS

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MAHMOUDZADEH AZIZ; POURFATH ELAH A.A.; ZAKERI F.

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Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 171-178

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Information Journal Paper

Title

SYNERGISTIC EFFECT OF Γ-INTERFERON AND ERYTHROPOIETIN ON DIFFERENTIATION OF K562 CELL LINE TREATED WITH CYTOTOXIC DRUGS

Author(s)

MAHMOUDZADEH AZIZ | POURFATH ELAH A.A. | ZAKERI F. | Issue Writer Certificate

Keywords

Γ-INTERFERONQ3

ERYTHROPOIETINQ2

CYTOTOXIC DRUGSQ2

DIFFERENTIATIONQ3

K562 CELL LINEQ4

Abstract

Leukemias are neoplasms that originate from malignant cells related to hematopoietic stem cells. Maturation of malignant cells is prematurely arrested and they merely proliferate. It is generally an accepted concept in oncology that the malignancy must be eliminated. In the recent decade, new therapeutic treatments have been introduced based on chemicals like cytokines and chemotherapeutic agents with less complications. This generally-accepted viewpoint in cancer treatment is called DIFFERENTIATION therapy. The present study is based on this method of treatment using cytokines and CYTOTOXIC DRUGS.The K562 cells were exposed to different concentrations of Γ-INTERFERON, ERYTHROPOIETIN, cytarabin, adriamycin and vincristin. After determination of optimum doses for these drugs, the cells were treated with them for 7 days and then cytospin smears were prepared from the cells and stained with benzidine and Wright methods and their DIFFERENTIATION was evaluated. For quantitative analysis of DIFFERENTIATION, rate of heme production was measured. For statistical analysis χ2 and student’s t-test were used.The results showed that although all of the above-mentioned drugs except vincristin can have differentiative effect compared to control group (P<0.05), but their combination decreases the DIFFERENTIATION.

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References

مقایسه روش های محرومیت از رنگ پذیری و رنگ سنجی تترازولیوم (MTT assay) جهت بررسی اثرات داروهای سیتوتوکسیک بر روی سلول های لوسمیک K562

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APA: Copy

MAHMOUDZADEH, AZIZ, POURFATH ELAH, A.A., & ZAKERI, F.. (2002). SYNERGISTIC EFFECT OF Γ-INTERFERON AND ERYTHROPOIETIN ON DIFFERENTIATION OF K562 CELL LINE TREATED WITH CYTOTOXIC DRUGS. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 171-178. SID. https://sid.ir/paper/74977/en

Vancouver: Copy

MAHMOUDZADEH AZIZ, POURFATH ELAH A.A., ZAKERI F.. SYNERGISTIC EFFECT OF Γ-INTERFERON AND ERYTHROPOIETIN ON DIFFERENTIATION OF K562 CELL LINE TREATED WITH CYTOTOXIC DRUGS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):171-178. Available from: https://sid.ir/paper/74977/en

IEEE: Copy

AZIZ MAHMOUDZADEH, A.A. POURFATH ELAH, and F. ZAKERI, “SYNERGISTIC EFFECT OF Γ-INTERFERON AND ERYTHROPOIETIN ON DIFFERENTIATION OF K562 CELL LINE TREATED WITH CYTOTOXIC DRUGS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 171–178, 2002, [Online]. Available: https://sid.ir/paper/74977/en

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