SERUM ALPHA-1-ANTITRYPSIN ISOENZYMES IN SUSPECTED LIVER DISEASE

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LOTFI A.S.; GHAVAMI S.; MALAKZADEH R.; KHODADAD A.

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Journal: KOWSAR MEDICAL JOURNAL Year:2002 | Volume:7 | Issue:part 1 Page(s): 35-40

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Title

SERUM ALPHA-1-ANTITRYPSIN ISOENZYMES IN SUSPECTED LIVER DISEASE

Author(s)

LOTFI A.S. | GHAVAMI S. | MALAKZADEH R. | KHODADAD A. | Issue Writer Certificate

Keywords

ALPHA-1-ANTITRYPSINQ4

IDIOPATIC LIVER DISEASESQ4

ISOELECTROFOCUSING.Q4

Abstract

ALPHA-1-ANTITRYPSIN (α1-AT) is the most important serine protease inhibitor in serum. This protein has several phenotypes. Some of these phenotypes such as MZ, M1Z, M1S, MS, ZZ, ... show the signs of α1-AT deficiency. In persons with α1-antitrypsin deficiency (AATD), many organ such as the liver, lung, kidney, ... may be damaged. In this study two groups were choosen. Group one had (49 patients) had idiopatic liver disease and group two 28 Patients were volunteers with normal liver tests. We have measured trypsin inhibitory capacity in both groups by enzymatic assay and then determined α1-AT phenotypes by ISOELECTROFOCUSING.(lEF) on polyacrylamide gel. By comparing α1-AT phenotypes between the two-groups we have observed significant differences in their phenotypes. But there was no significant difference between TIC of two groups. It can be concluded that persons with AATD are at high risk for liver disease development and α1-AT phenotypes must be evaluated by ISOELECTROFOCUSING. method.

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APA: Copy

LOTFI, A.S., GHAVAMI, S., MALAKZADEH, R., & KHODADAD, A.. (2002). SERUM ALPHA-1-ANTITRYPSIN ISOENZYMES IN SUSPECTED LIVER DISEASE. KOWSAR MEDICAL JOURNAL, 7(part 1), 35-40. SID. https://sid.ir/paper/33052/en

Vancouver: Copy

LOTFI A.S., GHAVAMI S., MALAKZADEH R., KHODADAD A.. SERUM ALPHA-1-ANTITRYPSIN ISOENZYMES IN SUSPECTED LIVER DISEASE. KOWSAR MEDICAL JOURNAL[Internet]. 2002;7(part 1):35-40. Available from: https://sid.ir/paper/33052/en

IEEE: Copy

A.S. LOTFI, S. GHAVAMI, R. MALAKZADEH, and A. KHODADAD, “SERUM ALPHA-1-ANTITRYPSIN ISOENZYMES IN SUSPECTED LIVER DISEASE,” KOWSAR MEDICAL JOURNAL, vol. 7, no. part 1, pp. 35–40, 2002, [Online]. Available: https://sid.ir/paper/33052/en

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