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Information Journal Paper

Title

Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk

Pages

  56-62

Abstract

 Type 2 diabetes mellitus (T2DM) is a complex disease that involves a wide range of genetic and environmental factors. The hepatocyte nuclear factor (HNF4A) carries out hepatic gluconeogenesis regulation and insulin secretion crucially, and the corresponding gene was shown to be linked to T2DM in several studies. The aim of the present study was to evaluate the association between HNF4A genetic variants (rs1884613 and rs1884614) and T2DM risk in a group of Iranian patients. This case-control study included 100 patients with T2DM and 100 control subjects. Genotyping of two single nucleotide polymorphisms (SNPs) (rs1884613 and rs1884614) of HNF4A was performed using the sequencing method. There was no statistically significant difference for allele and genotype distribution of the HNF4A common variants (rs1884613 and rs1884614) between subjects with and without T2DM (P=0. 9 and P=0. 9, respectively). Regarding diabetic complications, although the presence of mentioned polymorphisms increased the odds of developing ophthalmic complications and reduction of the odds of renal complications among diabetic patients, the mentioned risk was non-significant and cannot be generalized to the whole population. It seems that rs1884613 and rs1884614 polymorphisms are not associated with T2DM or its renal and ophthalmic complications. To investigate the precise influence of these polymorphisms, prospective cohorts with larger sample sizes are required.

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    APA: Copy

    Azizi, Seyedeh Mina, Sarhangi, Negar, AFSHARI, MAHDI, ABBASI, DAVOOD, Aghaei Meybodi, Hamid Reza, & HASANZAD, MANDANA. (2019). Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 8(supp), 56-62. SID. https://sid.ir/paper/332263/en

    Vancouver: Copy

    Azizi Seyedeh Mina, Sarhangi Negar, AFSHARI MAHDI, ABBASI DAVOOD, Aghaei Meybodi Hamid Reza, HASANZAD MANDANA. Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2019;8(supp):56-62. Available from: https://sid.ir/paper/332263/en

    IEEE: Copy

    Seyedeh Mina Azizi, Negar Sarhangi, MAHDI AFSHARI, DAVOOD ABBASI, Hamid Reza Aghaei Meybodi, and MANDANA HASANZAD, “Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 8, no. supp, pp. 56–62, 2019, [Online]. Available: https://sid.ir/paper/332263/en

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