مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Silibinin Upregulates E-Cadherin Expression in MKN-45 Human Gastric Cancer Cells

Pages

  41-46

Abstract

 Background and objectives: gastric cancer is currently known as one of the most important causes of cancer-driven death all over the world. In patients with gastric cancer, a significant proportion of death occurs due to metastasis. On the other hand, down modulated E-cadherin level has been reported as an important contributor to tumor cell invasion and metastasis. In this regard, the present work was aimed to evaluate the impact of silibinin, a flavonolignan with established anti-tumor efficacy, on cell viability and E-cadherin expression in the gastric cancer cell line MKN-45. Methods: To determine cell viability, MTT assay was performed 48 h after silibinin treatment (at concentrations of 100, 200 and 400 μ M). In addition, quantitative real-time PCR was done following total RNA extraction and cDNA synthesis, to assess E-cadherin level in cells treated with silibinin. Results: The MTT results showed concentration-dependent reducing effect of silibinin on viability of MKN-45 cells. The findings of quantitative real-time PCR analysis demonstrated upregulated E-cadherin expression in cells treated with silibinin (significantly (p≤ 0. 05) at concentration of 200 μ M) compared to the control cells. Conclusions: The current study suggested that silibinin may exert anti-migratory/invasive effects on gastric cancer cells by enhancing E-cadherin expression, which needs to be further investigated.

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    Cite

    APA: Copy

    FAGHIHLOO, EBRAHIM, MIRZAEI, HABIBOLLAH, AKBARI, ABOLFAZL, & GOUDARZI, HOSSEIN. (2018). Silibinin Upregulates E-Cadherin Expression in MKN-45 Human Gastric Cancer Cells. RESEARCH JOURNAL OF PHARMACOGNOSY, 5(3), 41-46. SID. https://sid.ir/paper/336822/en

    Vancouver: Copy

    FAGHIHLOO EBRAHIM, MIRZAEI HABIBOLLAH, AKBARI ABOLFAZL, GOUDARZI HOSSEIN. Silibinin Upregulates E-Cadherin Expression in MKN-45 Human Gastric Cancer Cells. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2018;5(3):41-46. Available from: https://sid.ir/paper/336822/en

    IEEE: Copy

    EBRAHIM FAGHIHLOO, HABIBOLLAH MIRZAEI, ABOLFAZL AKBARI, and HOSSEIN GOUDARZI, “Silibinin Upregulates E-Cadherin Expression in MKN-45 Human Gastric Cancer Cells,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 5, no. 3, pp. 41–46, 2018, [Online]. Available: https://sid.ir/paper/336822/en

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