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Information Journal Paper

Title

Pharmacognostic and Anti-Inflammatory Properties of Securigera securidaca Seeds and Seed Oil

Pages

  31-39

Abstract

 Background and objectives: Although weed plants are considered undesirable in a particular situation, some Weed seeds can be a valuable and cheap source of therapeutic natural compounds. Securigera securidaca (L. ) Degen & Dorfl (Fabaceae) is widely distributed in Europe, Australia and Asia as a weed plant. This study investigated the bioactive compounds of S. securidaca seeds as well as its potential anti-inflammatory properties. Methods: The fatty acid and sterol content were investigated with gas chromatography– mass spectrometry (GC-MS) and phenolic compounds were detected using high performance thin layer chromatography (HPTLC). The thermostability of the oil was studied using differential scanning calorimetry (DSC). Formalin-induced paw licking test and myeloperoxidase activity were investigated. The study was conducted by creating six groups of rats including a control group (vehicle-treated rats, 250 μ L/kg, i. p. ), formalin group (50 μ L of 2. 5% formalin), positive control (paracetamol, 100 mg/kg, i. p), and groups of S. securidaca seed oil (250, 500, 1000, 2000, and 4000 μ l/kg, i. p). Results: S. securidaca seeds contained a high level of polyunsaturated fatty acid content including linoleic acid (64. 602 ± 0. 793%) and oleic acid (15. 353 ± 0. 461%). Stigmasterol and campesterol were not detected in the oil but it contained esterified β-sitosterol (6. 621 ± 0. 08 mg/g). The seed oil couldn’ t create a significant reduction in the MPO activity. It showed a slight but not significant effect on formalin-induced pain reduction. Conclusion: The seed is a rich source of linoleic acid which makes it a good candidate to be used in the pharmaceutical industry.

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    APA: Copy

    JAMSHIDZADEH, AKRAM, PASDARAN, ARDALAN, HEIDARI, REZA, & HAMEDI, AZADEH. (2018). Pharmacognostic and Anti-Inflammatory Properties of Securigera securidaca Seeds and Seed Oil. RESEARCH JOURNAL OF PHARMACOGNOSY, 5(3), 31-39. SID. https://sid.ir/paper/336828/en

    Vancouver: Copy

    JAMSHIDZADEH AKRAM, PASDARAN ARDALAN, HEIDARI REZA, HAMEDI AZADEH. Pharmacognostic and Anti-Inflammatory Properties of Securigera securidaca Seeds and Seed Oil. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2018;5(3):31-39. Available from: https://sid.ir/paper/336828/en

    IEEE: Copy

    AKRAM JAMSHIDZADEH, ARDALAN PASDARAN, REZA HEIDARI, and AZADEH HAMEDI, “Pharmacognostic and Anti-Inflammatory Properties of Securigera securidaca Seeds and Seed Oil,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 5, no. 3, pp. 31–39, 2018, [Online]. Available: https://sid.ir/paper/336828/en

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