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Information Journal Paper

Title

Effect of Probiotics on Serum Bilirubin Level in Term Neonates with Jaundice: A Randomized Clinical Trial

Pages

  5925-5930

Abstract

 Background In recent years, the tendency to use drugs has been increasing in the treatment of neonatal Jaundice. Several drugs have been used since then, but the effect of Probiotics on serum Bilirubin level (SBL) is not so clear. This study was conducted to evaluate the effect of Probiotics on SBL and the duration of Phototherapy in term neonates with hyperBilirubinemia. Materials and Methods: In this randomized clinical trial, we studied 150 term neonate with Jaundice hospitalized for Phototherapy in Amirkola Children’ s Hospital, Babol-Iran, during October 5, 2016 till May 19, 2017. Eligible neonates were randomly divided into two; intervention (n=75), and control (n=75) groups. Both groups received standard conventional Phototherapy, but the intervention group received 10 drops/day of Probiotics (Pedilact Zisttakhmir. Co. Iran), until hospital discharge. The outcome variables were SBL and the duration of Phototherapy. The data were analyzed by SPSS 22. 0 and the P (0. 05 was considered significant. Results: The mean SBL before intervention in the intervention and control groups was 16 ± 1. 9 and 16. 9± 1. 9 mg/dl, respectively (P>0. 05). After 24, 48 and 72hours it decreased to 13. 73± 1. 72, 10. 92± 1. 87 and 10. 25± 1. 32 in the intervention and 13. 66± 1. 91, 11. 01± 1. 69 and10. 09± 1. 38 in the control groups, respectively, but a comparison of the amount of SBL reduction between the two groups was not significant (P>0. 05). The duration of Phototherapy in the intervention group and the control group was 3. 61± 1. 17 days and 3. 72± 1. 18 days respectively (P>0. 05). Conclusion Oral Probiotics in neonates with Jaundice have no significant effect on SBL and the duration of Phototherapy. Further studies are needed with longer time follow-up.

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    APA: Copy

    ZAHED PASHA, YADOLLAH, AHMADPOUR KACHO, MOUSA, Ahmadi Jazi, Abes, & GHOLINIA, HEMMAT. (2017). Effect of Probiotics on Serum Bilirubin Level in Term Neonates with Jaundice: A Randomized Clinical Trial. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(10 (46)), 5925-5930. SID. https://sid.ir/paper/337790/en

    Vancouver: Copy

    ZAHED PASHA YADOLLAH, AHMADPOUR KACHO MOUSA, Ahmadi Jazi Abes, GHOLINIA HEMMAT. Effect of Probiotics on Serum Bilirubin Level in Term Neonates with Jaundice: A Randomized Clinical Trial. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2017;5(10 (46)):5925-5930. Available from: https://sid.ir/paper/337790/en

    IEEE: Copy

    YADOLLAH ZAHED PASHA, MOUSA AHMADPOUR KACHO, Abes Ahmadi Jazi, and HEMMAT GHOLINIA, “Effect of Probiotics on Serum Bilirubin Level in Term Neonates with Jaundice: A Randomized Clinical Trial,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 5, no. 10 (46), pp. 5925–5930, 2017, [Online]. Available: https://sid.ir/paper/337790/en

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