مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

175
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

134
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Safety of Naloxone in Opioid-Naive Methadone Intoxicated Patients; a Case Series Study

Pages

  0-0

Abstract

 Introduction: Studies have shown that Naloxone can cause behavioral changes in naive normal volunteers. This study aimed to investigate the possible complications of Naloxone in methadone-overdosed Opioid-naive patients. Methods: In this pilot study, a total number of 20 Opioid-naive methadone-poisoned patients underwent Naloxone challenge test to receive naltrexone. 0. 2, 0. 6, and 1. 2 mg doses of Naloxone were administered on minutes 0, 5, and 15-20. The patients were followed for 30 minutes after administration of Naloxone and monitored for any upsetting signs and symptoms. Patients with clinical opiate withdrawal scale (COWS) lower than 5 were considered not addicted and the severity of patients’ symptoms was calculated using subjective opiate withdrawal syndrome (SOWS). Results: 20 patients with mean age of 25. 5§ 8. 09 years were evaluated (70% female). Median ingested dose of methadone was 25 mg [IQR; 10 to 50 mg] and mean time interval between ingestion of methadone and Naloxone challenge test was 7. 1§ 4. 9 hours. Fourteen patients reported some discomfort after administration of a mean dose of 1. 7§ 0. 5 mg of Naloxone lasting for a maximum of four hours. The most common patients’ complaints were headache (45%) followed by nausea (20%), agitation (20%), abdominal pain (20%), and flushing (20%). Two (10%) mentioned severe panic attack and sensation of near-coming death. SOWS significantly correlated with female gender (p = 0. 004) and time elapsed post methadone ingestion (p = 0. 001). Conclusion: It seems that Naloxone is not a completely safe medication even in Opioid-naive patients, and administrating adjusted doses of Naloxone even in Opioid-naive methadone intoxicated patientsmay be logical.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Shakeri, Seyed Hamid Reza, HASSANIAN MOGHADDAM, HOSSEIN, & ZAMANI, NASIM. (2020). Safety of Naloxone in Opioid-Naive Methadone Intoxicated Patients; a Case Series Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 8(1), 0-0. SID. https://sid.ir/paper/339887/en

    Vancouver: Copy

    Shakeri Seyed Hamid Reza, HASSANIAN MOGHADDAM HOSSEIN, ZAMANI NASIM. Safety of Naloxone in Opioid-Naive Methadone Intoxicated Patients; a Case Series Study. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/339887/en

    IEEE: Copy

    Seyed Hamid Reza Shakeri, HOSSEIN HASSANIAN MOGHADDAM, and NASIM ZAMANI, “Safety of Naloxone in Opioid-Naive Methadone Intoxicated Patients; a Case Series Study,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/339887/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button