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Information Journal Paper

Title

KOJIC ACID EFFECT ON THE INHIBITORY POTENCY OF TYROSINASE

Pages

  147-155

Abstract

 In recent years, enzymatic activity of TYROSINASE has been the focus of investigation due to its potential applications in medicine, agriculture and cosmetics. TYROSINASE, entitled poly-phenol oxidase, is a key enzyme that catalyzes synthesis of melanin in plants, microorganisms and mammalian cells. Presence of some antioxidants can delay or inhibit the activity of this enzyme as well. In this survey, MOLECULAR DOCKING calculation method using Autodock 4.0 software for prediction of BINDING ENERGY of the protein with some antioxidant ligands was executed. The pose with the lowest energy of binding or INHIBITION CONSTANT was extracted at 298.15 K for KOJIC ACID. Number of conformations in the cluster of rank was 13. The first and second boxes free energy and the INHIBITION CONSTANT were as follows: -5.60 kcalmol-1, 78.99 mM and -3.32 kcalmol-1, 3.66 mM, respectively. Since the first box presented a lower value of free energy, it was considered as the best mode of structure of KOJIC ACID and the protein docking for further analysis. Thus, our present study could contribute to development and discernment of TYROSINASE inhibitors in order to prevent hyper pigmentation.

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    APA: Copy

    AZAMI, FOROGH, TAZIKEH LEMESKI, ELHAM, & MAHMOOD JANLOU, MEHR ALI. (2017). KOJIC ACID EFFECT ON THE INHIBITORY POTENCY OF TYROSINASE. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), 7(2), 147-155. SID. https://sid.ir/paper/340329/en

    Vancouver: Copy

    AZAMI FOROGH, TAZIKEH LEMESKI ELHAM, MAHMOOD JANLOU MEHR ALI. KOJIC ACID EFFECT ON THE INHIBITORY POTENCY OF TYROSINASE. JOURNAL OF CHEMICAL HEALTH RISKS (JCHR)[Internet]. 2017;7(2):147-155. Available from: https://sid.ir/paper/340329/en

    IEEE: Copy

    FOROGH AZAMI, ELHAM TAZIKEH LEMESKI, and MEHR ALI MAHMOOD JANLOU, “KOJIC ACID EFFECT ON THE INHIBITORY POTENCY OF TYROSINASE,” JOURNAL OF CHEMICAL HEALTH RISKS (JCHR), vol. 7, no. 2, pp. 147–155, 2017, [Online]. Available: https://sid.ir/paper/340329/en

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