EXPRESSION OF APOPTOSIS-RELATED GENES BCL-2 AND BAX IN RAT BRAIN HIPPOCAMPUS, FOLLOWED BY INTRAPERITONEAL INJECTION OF NANOSILVER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHOSHCIAN MARYAM; KHODARAHMI PARVIN; TAFVIZI FARZANEH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2016 | Volume:19 | Issue:2 Page(s): 185-193

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

837

Download:

Cites:

Information Journal Paper

Title

EXPRESSION OF APOPTOSIS-RELATED GENES BCL-2 AND BAX IN RAT BRAIN HIPPOCAMPUS, FOLLOWED BY INTRAPERITONEAL INJECTION OF NANOSILVER

Author(s)

GHOSHCIAN MARYAM | KHODARAHMI PARVIN | TAFVIZI FARZANEH | Issue Writer Certificate

Keywords

SILVER NANOPARTICLESQ1

BCL-2 GENEQ1

BAX GENEQ2

SEMI-QUALITATIVE RT-PCRQ1

DENSITOMETRYQ1

Abstract

Background: SILVER NANOPARTICLES are small scale substance (<100 nm) used in food technology and medical industry. The data suggest that nanosilver may produce neurotoxicity by generating free radical-induced oxidative stress and by altering gene expression producing apoptosis and neurotoxicity. In this study, the apoptotic effects of Nano silver on apoptosis- related genes expression bcl-2 and bax on rat hippocampus, which is involved in memory and learning, was investigated.Materials & Methods: 28 male Wistar rats were divided into four groups of control and three groups of the treatment. The control group received saline and the treatment groups received intraperitoneal injections of SILVER NANOPARTICLES at doses of 100, 200 and 400ppm. Ten days after the last injection, the hippocampal region was dissected and removed and then the expression of bcl-2 and BAX GENEs was evaluated using SEMI-QUALITATIVE RT-PCR and DENSITOMETRY assay.Results: The expression of anti- apoptotic b-cl2 gene was reduced in the treatment groups compared to the control group. In comparison, the expression of pro- apoptotic BAX GENE was increased in the treatment groups compared to the control group. This apoptotic affects was increased at higher doses.Conclusion: The data suggest that SILVER NANOPARTICLES may produce apoptosis by altering apoptosis- related genes expression, in rat brain hippocampus cells.

Cites

No record.

References

INVESTIGATING THE EFFECT OF SILVER NANOPARTICLES ON E.COLI GROWTH

Cite

APA: Copy

GHOSHCIAN, MARYAM, KHODARAHMI, PARVIN, & TAFVIZI, FARZANEH. (2016). EXPRESSION OF APOPTOSIS-RELATED GENES BCL-2 AND BAX IN RAT BRAIN HIPPOCAMPUS, FOLLOWED BY INTRAPERITONEAL INJECTION OF NANOSILVER. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 19(2), 185-193. SID. https://sid.ir/paper/34155/en

Vancouver: Copy

GHOSHCIAN MARYAM, KHODARAHMI PARVIN, TAFVIZI FARZANEH. EXPRESSION OF APOPTOSIS-RELATED GENES BCL-2 AND BAX IN RAT BRAIN HIPPOCAMPUS, FOLLOWED BY INTRAPERITONEAL INJECTION OF NANOSILVER. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2016;19(2):185-193. Available from: https://sid.ir/paper/34155/en

IEEE: Copy

MARYAM GHOSHCIAN, PARVIN KHODARAHMI, and FARZANEH TAFVIZI, “EXPRESSION OF APOPTOSIS-RELATED GENES BCL-2 AND BAX IN RAT BRAIN HIPPOCAMPUS, FOLLOWED BY INTRAPERITONEAL INJECTION OF NANOSILVER,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 19, no. 2, pp. 185–193, 2016, [Online]. Available: https://sid.ir/paper/34155/en

Related Journal Papers