EVALUATION OF THE EXPANSION OF UMBILICAL CORD BLOOD DERIVED FROM CD133+ CELLS ON BIOCOMPATIBLE MICROWELLS

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SOUFI ZOMORROD MINA; SOLEIMANI MASOUD; ABROUN SAEID; MOSSAHEBI MOHAMMADI MAJID; KHAMISIPOUR GHOLAMREZA; MOBARRA NASER; BABASHAH SADEGH

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2016 | Volume:19 | Issue:2 Page(s): 296-305

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Title

EVALUATION OF THE EXPANSION OF UMBILICAL CORD BLOOD DERIVED FROM CD133+ CELLS ON BIOCOMPATIBLE MICROWELLS

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Keywords

UMBILICAL CORD BLOODQ2

CD133+ CELLSQ1

3 DIMENSIONAL MICROENVIRONMENTQ1

PDMSQ1

Abstract

Background: Hematopoietic stem cell transplantation (HSCT) is a therapeutic approach for treatment of hematological malignancies and incompatibility of Bone marrow. UMBILICAL CORD BLOOD (UCB) has known as an alternative for hematopoietic stem/progenitor cells (HPSC) in allogeneic transplantation. The low volume of collected samples is the main hindrance in application of HPSC derived from UMBILICAL CORD BLOOD. So, ex vivo expansion of HPSCs is the useful approach to overcome this restriction. The goal of using this system is to produce appropriate amount of hematopoietic stem cells, which have the ability of transplantation and long term haematopoiesis.Material & Methods: In current study CD133+ cells were isolated from cord blood (CB). Isolated cells were seeded on microwells. Then expanded cells proliferation rate and ability in colony formation were assessed and finally were compared with 2 Dimensional (2D) culture systems.Results: Our findings demonstrated that CD133+ cells derived from UCB which were cultivated on microwells had significantly higher rate of proliferation in compared with routine cell culture systems.Conclusion: In Current study, it was shown that CD133+ cells’ proliferations which were seeded on PDMS microwells coated with collagen significantly increased. We hope that 3 dimensional (3D) microenvironment which mimics the 3D structure of bone marrow can solve the problem of using UCB as an alternative source of bone marrow.

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APA: Copy

SOUFI ZOMORROD, MINA, SOLEIMANI, MASOUD, ABROUN, SAEID, MOSSAHEBI MOHAMMADI, MAJID, KHAMISIPOUR, GHOLAMREZA, MOBARRA, NASER, & BABASHAH, SADEGH. (2016). EVALUATION OF THE EXPANSION OF UMBILICAL CORD BLOOD DERIVED FROM CD133+ CELLS ON BIOCOMPATIBLE MICROWELLS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 19(2), 296-305. SID. https://sid.ir/paper/34159/en

Vancouver: Copy

SOUFI ZOMORROD MINA, SOLEIMANI MASOUD, ABROUN SAEID, MOSSAHEBI MOHAMMADI MAJID, KHAMISIPOUR GHOLAMREZA, MOBARRA NASER, BABASHAH SADEGH. EVALUATION OF THE EXPANSION OF UMBILICAL CORD BLOOD DERIVED FROM CD133+ CELLS ON BIOCOMPATIBLE MICROWELLS. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2016;19(2):296-305. Available from: https://sid.ir/paper/34159/en

IEEE: Copy

MINA SOUFI ZOMORROD, MASOUD SOLEIMANI, SAEID ABROUN, MAJID MOSSAHEBI MOHAMMADI, GHOLAMREZA KHAMISIPOUR, NASER MOBARRA, and SADEGH BABASHAH, “EVALUATION OF THE EXPANSION OF UMBILICAL CORD BLOOD DERIVED FROM CD133+ CELLS ON BIOCOMPATIBLE MICROWELLS,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 19, no. 2, pp. 296–305, 2016, [Online]. Available: https://sid.ir/paper/34159/en

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