LUTETIUM-177 DOTATATE PRODUCTION WITH AN AUTOMATED RADIOPHARMACEUTICAL SYNTHESIS SYSTEM

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ASLANI ALIREZA; SNOWDON GRAEME M.; BAILEY DALE L.; SCHEMBRI GEOFFREY P.; BAILEY ELIZABETH A.; PAVLAKIS NICK; ROACH PAUL J.

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Journal: ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE & BIOLOGY Year:2015 | Volume:3 | Issue:2 Page(s): 107-115

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Title

LUTETIUM-177 DOTATATE PRODUCTION WITH AN AUTOMATED RADIOPHARMACEUTICAL SYNTHESIS SYSTEM

Author(s)

Keywords

AUTOMATED SYNTHESIS

LUTETIUM-DOTATATE

NEUROENDOCRINE TUMOURS

PEPTIDE RECEPTOR RADIONUCLIDE THERAPY

Abstract

Objective(s): Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 (90Y) and lutetium-177 (177Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radio pharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system.Methods: All syntheses were carried out using the Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) 177Lu was used with GMPcertified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLCSG and HPLC methods.Results: A total of 17 [177Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [177Lu]- DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8±0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3±1.5%) for this period.Conclusions: The automated synthesis of [177Lu]-DOTATATE using Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA 177Lu and almost negligible radiation exposure of the operators.

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APA: Copy

SNOWDON, GRAEME M., BAILEY, DALE L., SCHEMBRI, GEOFFREY P., BAILEY, ELIZABETH A., PAVLAKIS, NICK, & ROACH, PAUL J.. (2015). LUTETIUM-177 DOTATATE PRODUCTION WITH AN AUTOMATED RADIOPHARMACEUTICAL SYNTHESIS SYSTEM. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, 3(2), 107-115. SID. https://sid.ir/paper/342064/en

Vancouver: Copy

SNOWDON GRAEME M., BAILEY DALE L., SCHEMBRI GEOFFREY P., BAILEY ELIZABETH A., PAVLAKIS NICK, ROACH PAUL J.. LUTETIUM-177 DOTATATE PRODUCTION WITH AN AUTOMATED RADIOPHARMACEUTICAL SYNTHESIS SYSTEM. ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY[Internet]. 2015;3(2):107-115. Available from: https://sid.ir/paper/342064/en

IEEE: Copy

GRAEME M. SNOWDON, DALE L. BAILEY, GEOFFREY P. SCHEMBRI, ELIZABETH A. BAILEY, NICK PAVLAKIS, and PAUL J. ROACH, “LUTETIUM-177 DOTATATE PRODUCTION WITH AN AUTOMATED RADIOPHARMACEUTICAL SYNTHESIS SYSTEM,” ASIA OCEANIA JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 3, no. 2, pp. 107–115, 2015, [Online]. Available: https://sid.ir/paper/342064/en

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