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Information Journal Paper

Title

EFFECT OF EXERCISE TRAINING ON BCL-2 AND BAX GENE EXPRESSION IN THE RAT HEART

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Abstract

 Background: APOPTOSIS or programmed cell death plays an important role in the development of cardiovascular diseases, particularly heart failure. Current evidence suggests that EXERCISE training may alter APOPTOSIS-related signaling in sensitive somatic tissues such as the MYOCARDIUM.Objectives: The aim of this study was to assess the effect of EXERCISE training on Bcl-2 and Bax genes expression as key molecules involved in intrinsic pathway of APOPTOSIS in the rat heart.Materials and Methods: This study was conducted with a two-group experimental design (animal model) and sixteen three-month-old male rats were selected and randomly divided to two groups of EXERCISE training (n = 8) and control (n = 8). Rats in the trained group participated in an EXERCISE training program for 12 weeks (10 – 60 m min-1, 24 – 33 min d-1, 15%). The rat hearts were removed forty-eight hours after the last training session. RNA extraction and synthesis of cDNA was done, and Bax and Bcl2 genes expression was analyzed through the Real Time-Polymerase Chain Reaction (RT-PCR). Kolmogorov-Smirnov and independent t-test were applied for statistical analysis of the data (P < 0.05).Results: The results showed that Bax gene expression and Bax/Bcl2 ratio of the trained group were significantly lower than the control group, 81% and 89%, respectively (P < 0.05). Moreover, there was no significant difference between the two groups in Bcl2 (P > 0.05). However, Bcl2 expression was higher in the trained group compared to the control group (11%).Conclusions: In general, it seems that three-month EXERCISE training was effective in reducing cardiac mitochondrial pro-apoptotic protein. However, considering the results of the Bcl2 gene expression, more researches are needed to identify effects of EXERCISE trainings on indices of myocardial APOPTOSIS.

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    APA: Copy

    JAFARI, AFSHAR, POURRAZI, HASSAN, NIKOOKHESLAT, SAEID, & BARADARAN, BEHZAD. (2015). EFFECT OF EXERCISE TRAINING ON BCL-2 AND BAX GENE EXPRESSION IN THE RAT HEART. GENE, CELL AND TISSUE, 2(4), 0-0. SID. https://sid.ir/paper/345086/en

    Vancouver: Copy

    JAFARI AFSHAR, POURRAZI HASSAN, NIKOOKHESLAT SAEID, BARADARAN BEHZAD. EFFECT OF EXERCISE TRAINING ON BCL-2 AND BAX GENE EXPRESSION IN THE RAT HEART. GENE, CELL AND TISSUE[Internet]. 2015;2(4):0-0. Available from: https://sid.ir/paper/345086/en

    IEEE: Copy

    AFSHAR JAFARI, HASSAN POURRAZI, SAEID NIKOOKHESLAT, and BEHZAD BARADARAN, “EFFECT OF EXERCISE TRAINING ON BCL-2 AND BAX GENE EXPRESSION IN THE RAT HEART,” GENE, CELL AND TISSUE, vol. 2, no. 4, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/345086/en

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