THE EFFECT OF AEROBIC EXERCISE AND MELATONIN CONSUMPTION ON THE EXPRESSION OF BAX AND BCL-2 MARKERS IN RAT MYOCARD AFTER ISCHEMIA-REPERFUSION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ALIZADEH PAHLAVANI HAMED; RAJABI HAMID; NABIUNI MOHAMMAD; MOTAMEDI PEZHMAN; KHALEDI NEDA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2017 | Volume:35 | Issue:423 Page(s): 318-325

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

878

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF AEROBIC EXERCISE AND MELATONIN CONSUMPTION ON THE EXPRESSION OF BAX AND BCL-2 MARKERS IN RAT MYOCARD AFTER ISCHEMIA-REPERFUSION

Author(s)

Keywords

APOPTOSISQ1

AEROBIC EXERCISEQ1

MELATONINQ2

Abstract

Background: This research aimed to examine the effect of AEROBIC EXERCISE and MELATONIN consumption on the expression of Bax and Bcl-2 markers in rat myocard after ischemia-reperfusion by isoprenaline.Methods: 30 two- to three-months-old male Wistar rats were used weighing approximately 200-250 g. They were divided into five groups of pilot (n=14), control (n=4), MELATONIN (n=4), aerobic (n=4), and MELATONIN-aerobic (n=4). Rats in MELATONIN and MELATONIN-aerobic groups were gavaged every day for one month using a dose of 10 mg per kg body-weight. Meanwhile, rats in aerobic and MELATONIN-aerobic groups were familiar with running on treadmill for one week, and then, they were exposed training course with frequency of three times weekly for one month. After one month, all the rats were injected isoprenaline with dose of 150 and 125 mg per kg body-weight in two consecutive days with 24-hours interval. Finally, rats were sacrificed after confirmation of infarct. Expression of Bax and Bcl-2 gene were studied via real-time polymerase chain reaction method. Data were analyzed using 2-DDct formula and one-way ANOVA and Kruskal-Wallis tests.Findings: Separately, MELATONIN treatment and aerobic training had negligible effect on expression of Bax and Bcl-2 genes. But, combination of AEROBIC EXERCISE and MELATONIN significantly decreased and increased the expression of Bax and Bcl-2 genes, respectively, compared to treatment with MELATONIN alone.Conclusion: However, it seems that AEROBIC EXERCISE with consuming MELATONIN in a longer term can reduce the amount of possible myocardial infarction.

Cites

No record.

References

Cite

APA: Copy

ALIZADEH PAHLAVANI, HAMED, RAJABI, HAMID, NABIUNI, MOHAMMAD, MOTAMEDI, PEZHMAN, & KHALEDI, NEDA. (2017). THE EFFECT OF AEROBIC EXERCISE AND MELATONIN CONSUMPTION ON THE EXPRESSION OF BAX AND BCL-2 MARKERS IN RAT MYOCARD AFTER ISCHEMIA-REPERFUSION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(423), 318-325. SID. https://sid.ir/paper/49709/en

Vancouver: Copy

ALIZADEH PAHLAVANI HAMED, RAJABI HAMID, NABIUNI MOHAMMAD, MOTAMEDI PEZHMAN, KHALEDI NEDA. THE EFFECT OF AEROBIC EXERCISE AND MELATONIN CONSUMPTION ON THE EXPRESSION OF BAX AND BCL-2 MARKERS IN RAT MYOCARD AFTER ISCHEMIA-REPERFUSION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(423):318-325. Available from: https://sid.ir/paper/49709/en

IEEE: Copy

HAMED ALIZADEH PAHLAVANI, HAMID RAJABI, MOHAMMAD NABIUNI, PEZHMAN MOTAMEDI, and NEDA KHALEDI, “THE EFFECT OF AEROBIC EXERCISE AND MELATONIN CONSUMPTION ON THE EXPRESSION OF BAX AND BCL-2 MARKERS IN RAT MYOCARD AFTER ISCHEMIA-REPERFUSION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 423, pp. 318–325, 2017, [Online]. Available: https://sid.ir/paper/49709/en

Related Journal Papers