EFFECT OF MTHFR C677T POLYMORPHISM ON METHYLATION STATUS OF E-CADHERIN IN GASTRIC CANCER

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SHABANIZADEH AHMAD; TAGHAVI MOHAMMAD MOHSEN; SHARIATI KOHBANANI MAHDI; TAGHIPOUR ZAHRA; JAFARI NAVEH HAMID REZA; MOLLAHOSSENI AKRAM; SALAHSHOOR MOHAMMAD REZA; JALILI CYRUS

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Journal: Gene, Cell and Tissue Year:2016 | Volume:3 | Issue:4 Page(s): 1-5

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Title

EFFECT OF MTHFR C677T POLYMORPHISM ON METHYLATION STATUS OF E-CADHERIN IN GASTRIC CANCER

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Keywords

GASTRIC CARCINOMA

METHYLATION

E-CADHERIN

MTHFR

Abstract

Background: MTHFR gene is one of the main and effective factors in genes METHYLATION. This gene has a common polymorphism in cordon 677, which can affect its activity. Changing activity rate of this gene can affect METHYLATION rate of tumor suppressor genes and cell membrane proteins and other genes in addition to their expression rate. Therefore, it can be considered as one of the effective factors on producing cancer.Methods: In this descriptive-cross sectional study, 34 cancer and non-cancer tissue samples were studied. Initially, DNA was extracted from samples and then E-CADHERIN and MTHFR c677t polymorphism were amplified by the polymerase chain reaction (PCR).Methylation status of E-CADHERIN was evaluated by adding METHYLATION restriction enzymeHpaII and polymorphism of MTHFRc677t was assessment by the restriction fragment length polymorphism (RFLP) method.Results: METHYLATION status of E-CADHERIN gene numbers of methylated cases in the cancer group were equal to one and unmethylated cases equal to 33 and numbers of unmethylated cases in the non-cancer group was equal to 34 while there were no methylated cases. In assessment of METHYLATION status of E-CADHERIN and different genotypes of MTHFR in codon number 677 in cancer samples, number of CC, CT and TT genotypes were equal to 0, 1 and 0 in the methylated group and equal to 6, 27 and 1 in the unmethylated group, respectively.Conclusions: According to this observation, another factor such as oncogenes activitymaycause cancer in samples but CT genotype of MTHFR can be considered as an effective factor in creating cancer.

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APA: Copy

SHABANIZADEH, AHMAD, TAGHAVI, MOHAMMAD MOHSEN, SHARIATI KOHBANANI, MAHDI, TAGHIPOUR, ZAHRA, JAFARI NAVEH, HAMID REZA, MOLLAHOSSENI, AKRAM, SALAHSHOOR, MOHAMMAD REZA, & JALILI, CYRUS. (2016). EFFECT OF MTHFR C677T POLYMORPHISM ON METHYLATION STATUS OF E-CADHERIN IN GASTRIC CANCER. GENE, CELL AND TISSUE, 3(4), 1-5. SID. https://sid.ir/paper/345177/en

Vancouver: Copy

SHABANIZADEH AHMAD, TAGHAVI MOHAMMAD MOHSEN, SHARIATI KOHBANANI MAHDI, TAGHIPOUR ZAHRA, JAFARI NAVEH HAMID REZA, MOLLAHOSSENI AKRAM, SALAHSHOOR MOHAMMAD REZA, JALILI CYRUS. EFFECT OF MTHFR C677T POLYMORPHISM ON METHYLATION STATUS OF E-CADHERIN IN GASTRIC CANCER. GENE, CELL AND TISSUE[Internet]. 2016;3(4):1-5. Available from: https://sid.ir/paper/345177/en

IEEE: Copy

AHMAD SHABANIZADEH, MOHAMMAD MOHSEN TAGHAVI, MAHDI SHARIATI KOHBANANI, ZAHRA TAGHIPOUR, HAMID REZA JAFARI NAVEH, AKRAM MOLLAHOSSENI, MOHAMMAD REZA SALAHSHOOR, and CYRUS JALILI, “EFFECT OF MTHFR C677T POLYMORPHISM ON METHYLATION STATUS OF E-CADHERIN IN GASTRIC CANCER,” GENE, CELL AND TISSUE, vol. 3, no. 4, pp. 1–5, 2016, [Online]. Available: https://sid.ir/paper/345177/en

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