Gain-of-Function R990G Polymorphism of the Calcium-Sensing Receptor Gene: Gender-Related Effects in Patients with Coronary Heart Disease

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Aslan Ezgi Irmak; COSKUNPINAR ENDER; Gomleksiz Ozlem Kurnaz; Tiryakioglu Ozan; Bugra Zehra; Ozturk Oguz; Aydogan Hulya Yilmaz

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Gene, Cell and Tissue Year:2018 | Volume:5 | Issue:2 Page(s): 0-0

Download Full-Text

View:

367

Download:

Cites:

Information Journal Paper

Title

Gain-of-Function R990G Polymorphism of the Calcium-Sensing Receptor Gene: Gender-Related Effects in Patients with Coronary Heart Disease

Author(s)

Keywords

CaSR

Gene

Gain of Function

Coronary Heart Disease

Hypertension

Abstract

Background: Activating the calcium-sensing receptor (CaSR), which regulates extracellular calcium, has been suggested to possibly decrease renin expression, thus playing a role in regulating the blood pressure via the renin-angiotensin-aldosterone system. Objectives: Considering this hypothesis, the aim of this study was to find the relationship between the gain-of-function variation of the CaSR Gene, R990G (A < G), and Coronary Heart Disease (CHD) risk factors and complications. Methods: The study sample consisted of 121 CHD patients and 105 healthy people from Turkish population. R990G function-gain mutation of the CaSR Gene was analyzed by the real-time PCR method. Results: The AA genotype of CaSR R990G variation was associated with higher LDL-C, SBP, DBP and lower HDL-C in the CHD group compared to controls (P < 0. 001). The comparison by gender in theCHDgroup revealed increased systolic blood pressure inwomen with common AA genotype as compared to men (P = 0. 008) whereas in the control group, higher HDL-C and lower serum LDL-C (P < 0. 001 and 0. 031, respectively) were observed in women with AA versus men with AA. Higher blood pressure levels in women were not sustained in G allele carriers compared to men with G allele (P > 0. 05). Conclusions: The common AA genotype of CaSR R990G was found to be related to Hypertension in CHD patients while showing a higher association with Hypertension, especially in women. We also suggest that the CaSR R990G AA genotype may have diverse effects on serum lipids and that the Genetic effect could differ by gender.

Cites

No record.

References

No record.

Cite

APA: Copy

Aslan, Ezgi Irmak, COSKUNPINAR, ENDER, Gomleksiz, Ozlem Kurnaz, Tiryakioglu, Ozan, Bugra, Zehra, Ozturk, Oguz, & Aydogan, Hulya Yilmaz. (2018). Gain-of-Function R990G Polymorphism of the Calcium-Sensing Receptor Gene: Gender-Related Effects in Patients with Coronary Heart Disease. GENE, CELL AND TISSUE, 5(2), 0-0. SID. https://sid.ir/paper/345190/en

Vancouver: Copy

Aslan Ezgi Irmak, COSKUNPINAR ENDER, Gomleksiz Ozlem Kurnaz, Tiryakioglu Ozan, Bugra Zehra, Ozturk Oguz, Aydogan Hulya Yilmaz. Gain-of-Function R990G Polymorphism of the Calcium-Sensing Receptor Gene: Gender-Related Effects in Patients with Coronary Heart Disease. GENE, CELL AND TISSUE[Internet]. 2018;5(2):0-0. Available from: https://sid.ir/paper/345190/en

IEEE: Copy

Ezgi Irmak Aslan, ENDER COSKUNPINAR, Ozlem Kurnaz Gomleksiz, Ozan Tiryakioglu, Zehra Bugra, Oguz Ozturk, and Hulya Yilmaz Aydogan, “Gain-of-Function R990G Polymorphism of the Calcium-Sensing Receptor Gene: Gender-Related Effects in Patients with Coronary Heart Disease,” GENE, CELL AND TISSUE, vol. 5, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/345190/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops