COMPARISON OF ANTIOXIDANT EFFECT OF MELISSA OFFICINALIS LEAF AND VITAMIN C IN LEAD ACETATEINDUCED LEARNING DEFICITS IN RAT

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ROSTAMI SAREH; MOMENI ZEINAB; BEHNAM RASSOULI MORTEZA; GHAYOUR NARGESS

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2010 | Volume:17 | Issue:86 Page(s): 47-54

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Title

COMPARISON OF ANTIOXIDANT EFFECT OF MELISSA OFFICINALIS LEAF AND VITAMIN C IN LEAD ACETATEINDUCED LEARNING DEFICITS IN RAT

Author(s)

ROSTAMI SAREH | MOMENI ZEINAB | BEHNAM RASSOULI MORTEZA | GHAYOUR NARGESS | Issue Writer Certificate

Keywords

ANTIOXIDANTQ2

MELISSA OFFICINALISQ3

VITAMIN CQ3

LEARNING DEFICITSQ3

LEAD ACETATEQ2

Abstract

Background & Objective: It has been established that oxidants have deleterious effects on learning and memory. Lead can also exert such effects through oxidative stress. This research was designed to compare the potential ANTIOXIDANT effects of MELISSA OFFICINALIS and VITAMIN C on LEARNING DEFICITS induced by LEAD ACETATE in fetal and neonatal periods.Materials & Methods: Fifteen mated Wistar rats were divided into control and 4 experimental groups as follows; Melissa (M) (1.5% in standard rat food formula), lead (Pb)-exposed (0.2% in drinking water), M+Pb group and a positive control group (Pb+vitamin C). Treatment started from 7th day of gestation and continued during pregnancy and lactation. After that, the learning abilities and memory retention of fourmonth old male offspring were studied using a complex T-maze.Results: There were significant differences between lead-exposed and other groups in the time of goal reaching and the number of errors (p<0.05) while there was no significant difference between the other groups.Conclusion: Since L+M group did not show any significant difference when compared to L+vitamin C group and melissa showed similar effects as VITAMIN C, it can be considered as a natural ANTIOXIDANT product.

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APA: Copy

ROSTAMI, SAREH, MOMENI, ZEINAB, BEHNAM RASSOULI, MORTEZA, & GHAYOUR, NARGESS. (2010). COMPARISON OF ANTIOXIDANT EFFECT OF MELISSA OFFICINALIS LEAF AND VITAMIN C IN LEAD ACETATEINDUCED LEARNING DEFICITS IN RAT. DANESHVAR MEDICINE, 17(86), 47-54. SID. https://sid.ir/paper/356697/en

Vancouver: Copy

ROSTAMI SAREH, MOMENI ZEINAB, BEHNAM RASSOULI MORTEZA, GHAYOUR NARGESS. COMPARISON OF ANTIOXIDANT EFFECT OF MELISSA OFFICINALIS LEAF AND VITAMIN C IN LEAD ACETATEINDUCED LEARNING DEFICITS IN RAT. DANESHVAR MEDICINE[Internet]. 2010;17(86):47-54. Available from: https://sid.ir/paper/356697/en

IEEE: Copy

SAREH ROSTAMI, ZEINAB MOMENI, MORTEZA BEHNAM RASSOULI, and NARGESS GHAYOUR, “COMPARISON OF ANTIOXIDANT EFFECT OF MELISSA OFFICINALIS LEAF AND VITAMIN C IN LEAD ACETATEINDUCED LEARNING DEFICITS IN RAT,” DANESHVAR MEDICINE, vol. 17, no. 86, pp. 47–54, 2010, [Online]. Available: https://sid.ir/paper/356697/en

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