EVALUATION OF HBME-1 IN THE DIFFERENTIAL DIAGNOSIS OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN BODY SEROUS EFFUSIONS

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RAHMANI ALI REZA; DEHGHANI M.; AFSHAR MOGHADAM N.; HEYDARIAN H.R.

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Journal: Journal of Isfahan Medical School Year:2010 | Volume:28 | Issue:105 Page(s): 0-0

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Title

EVALUATION OF HBME-1 IN THE DIFFERENTIAL DIAGNOSIS OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN BODY SEROUS EFFUSIONS

Author(s)

RAHMANI ALI REZA | DEHGHANI M. | AFSHAR MOGHADAM N. | HEYDARIAN H.R. | Issue Writer Certificate

Keywords

SEROUS FLUIDQ3

ADENOCARCINOMAQ3

REACTIVE MESOTHELIALQ3

HBME-1 ANTIGENQ3

IMMUNOCYTOCHEMISTRYQ3

Abstract

Background: We tried to evaluate the diagnostic utility of HBME-1 in distinguishing between REACTIVE MESOTHELIAL cells and ADENOCARCINOMA in body serous effusions.Methods: We examined 52 cytologic specimens of serous effusions processed by cell block technique retrieved from the pathology archive of Al-zahra hospital (Isfahan). They were categorized in two groups: Group I. 26 effusions containing REACTIVE MESOTHELIAL cells from patients with no evidences of malignancy based on cytomorphology, clinical data and imaging; and Group II. 26 effusions containing ADENOCARCINOMAtous cells from patients with diagnosis established by routine histology. Immunostaining with HBME-1 was performed using an Envision technique. Statistical analysis was performed with SPSS software. Findings: Statistical significance was found with HBME-1 when comparing both ADENOCARCINOMA versus mesothelial cells (P = 0.001). Also, we found HBME-1 outlined cell membranes in REACTIVE MESOTHELIAL cells versus cytoplasmic pattern in ADENOCARCINOMA cells (P = 0.001). The staining intensity for adenocarcimoma cells included: Negative in 7 cases (26.9%); score + in 4 cases (15.38%), score ++ in 11 cases (42.30%) and score +++ in 4 cases (15.38%). In mesothelial cells, Negative and score + was not seen, score ++ was in 3 cases (11.5%), and score +++ in 23 cases (88.5%) (P = 0.001). Conclusion: The staining pattern and intensity for HBME-1 is a usufull panel for differentiation of ADENOCARCINOMA and mesothelial cells. The only limitation of this marker is ovarian carcinoma that shows the same pattern as REACTIVE MESOTHELIAL cells.

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APA: Copy

RAHMANI, ALI REZA, DEHGHANI, M., AFSHAR MOGHADAM, N., & HEYDARIAN, H.R.. (2010). EVALUATION OF HBME-1 IN THE DIFFERENTIAL DIAGNOSIS OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN BODY SEROUS EFFUSIONS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 28(105), 0-0. SID. https://sid.ir/paper/359007/en

Vancouver: Copy

RAHMANI ALI REZA, DEHGHANI M., AFSHAR MOGHADAM N., HEYDARIAN H.R.. EVALUATION OF HBME-1 IN THE DIFFERENTIAL DIAGNOSIS OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN BODY SEROUS EFFUSIONS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2010;28(105):0-0. Available from: https://sid.ir/paper/359007/en

IEEE: Copy

ALI REZA RAHMANI, M. DEHGHANI, N. AFSHAR MOGHADAM, and H.R. HEYDARIAN, “EVALUATION OF HBME-1 IN THE DIFFERENTIAL DIAGNOSIS OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN BODY SEROUS EFFUSIONS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 28, no. 105, pp. 0–0, 2010, [Online]. Available: https://sid.ir/paper/359007/en

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