CLINICOPATHOLOGICAL SIGNIFICANCE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 GENE POLYMORPHISM IN BREAST CANCER PATIENTS FROM NORTH WEST OF IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

YOUNESI MAHDIEH; HOSSEINPOUR FEIZI MOHAMMADALI; POULADI NASSER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download Full-Text

Persian Verion

View:

711

Download:

Cites:

Information Journal Paper

Title

CLINICOPATHOLOGICAL SIGNIFICANCE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 GENE POLYMORPHISM IN BREAST CANCER PATIENTS FROM NORTH WEST OF IRAN

Author(s)

YOUNESI MAHDIEH | HOSSEINPOUR FEIZI MOHAMMADALI | POULADI NASSER | Issue Writer Certificate

Keywords

PAI-1 4G/5G POLYMORPHISMQ1

BREAST CANCERQ2

CLINICAL STATUSQ3

Abstract

Introduction: A common polymorphism 4G/5G in the promoter region of the Plasminogen activator inhibitor-1 (PAI-1) gene has been reported to influence the expression levels of PAI-1. According to the evidence, progression of BREAST CANCER can be associated with elevated levels of PAI-1, it seems that evaluation of a possible correlation between the polymorphism and CLINICAL STATUS of BREAST CANCER patients is reasonable.Methods: This descriptive-analytical study included 160 unrelated patients from North West of Iran. According to established clinical criteria, these paitients were diagnosed with BREAST CANCER. Based on previous study, PAI-1 4G/5G had been determined. In order to investigate the association of this polymorphism with clinicopathological features Fisher’s exact tests and SPSS software was used with a significance level of 0.05.Results: All declared features of BREAST CANCER regarding PAI-1 4G/5G POLYMORPHISM were investigated. Results indicated that PAI-1 4G/5G POLYMORPHISM positive correlation with several traditional prognostic factors, including tumor size, lymph node metastases and tumor stage.Conclusion: Data showed that the patients with 5G/5G genotype are more susceptible to the development of BREAST CANCER, while the paitients with 4G/4G and 4G/5G genotypes show lower sensitivity to the BREAST CANCER. Therefore, the 4G allele likely has a protective role against the development of BREAST CANCER in this cohort.

Cites

No record.

References

No record.

Cite

APA: Copy

YOUNESI, MAHDIEH, HOSSEINPOUR FEIZI, MOHAMMADALI, & POULADI, NASSER. (2016). CLINICOPATHOLOGICAL SIGNIFICANCE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 GENE POLYMORPHISM IN BREAST CANCER PATIENTS FROM NORTH WEST OF IRAN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(3), 277-285. SID. https://sid.ir/paper/35912/en

Vancouver: Copy

YOUNESI MAHDIEH, HOSSEINPOUR FEIZI MOHAMMADALI, POULADI NASSER. CLINICOPATHOLOGICAL SIGNIFICANCE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 GENE POLYMORPHISM IN BREAST CANCER PATIENTS FROM NORTH WEST OF IRAN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(3):277-285. Available from: https://sid.ir/paper/35912/en

IEEE: Copy

MAHDIEH YOUNESI, MOHAMMADALI HOSSEINPOUR FEIZI, and NASSER POULADI, “CLINICOPATHOLOGICAL SIGNIFICANCE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 GENE POLYMORPHISM IN BREAST CANCER PATIENTS FROM NORTH WEST OF IRAN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 3, pp. 277–285, 2016, [Online]. Available: https://sid.ir/paper/35912/en

Related Journal Papers