ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B1 GENE POLYMORPHISM (RS401502 C/G) AND CHRONIC HEPATITIS B VIRUS INFECTION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALEHI MOJTABA; RAVANSHAD MEHRDAD; MOHEBBI SEYED REZA; ZALI MOHAMMAD REZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:24 | Issue:3 Page(s): 269-276

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,004

Download:

Cites:

Information Journal Paper

Title

ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B1 GENE POLYMORPHISM (RS401502 C/G) AND CHRONIC HEPATITIS B VIRUS INFECTION

Author(s)

SALEHI MOJTABA | RAVANSHAD MEHRDAD | MOHEBBI SEYED REZA | ZALI MOHAMMAD REZA | Issue Writer Certificate

Keywords

HEPATITIS B VIRUSQ3

SINGLE NUCLEOTIDE POLYMORPHISMSQ2

IL-12 RECEPTOR B1Q1

CHRONIC HEPATITISQ2

Abstract

Introduction: HEPATITIS B VIRUS (HBV) infection is a major health problem worldwide and may lead to serious clinical complications, including CHRONIC HEPATITIS, liver cirrhosis, and hepatocellular carcinoma. The host’s genetic background in immune system genes is a crucial etiologic factor in progression of HBV infection to chronic disease or clearance of the virus from the body. Interleukin 12 and its receptor (IL12 Receptor) play an important role in the clearance of viral infections, especially HBV. The aim of this study is to investigate the association between interleukin 12 receptor B1 gene single nucleotide polymorphism (rs401502 C/G) and chronic HBV infection.Methods: In this case control study, genomic DNA of 105 chronically HBV infected patients and 105 healthy controls was extracted. Genotype of (rs401502 C/G) single nucleotide polymorphism was determined using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.Results: The frequency of (rs401502 C/G) SNP for GG, GC, CC genotypes and G, C alleles was %53.3, %41, %5.7 and %73.3, %26.7 in the chronic patients and %51.4, %41, %7.6 %71.9, and %28.1 in the control group, respectively. Statistical analysis of the results showed that there was not any significant difference between the case and control groups (p=0.851).Conclusion: In this study, no association was found between (rs401502 C/G) single nucleotide polymorphism within IL12RB1 gene and chronic HEPATITIS B VIRUS infection. It seems that this SNP does not play a crucial role in susceptibility to HBV chronic infection.

Cites

No record.

References

No record.

Cite

APA: Copy

SALEHI, MOJTABA, RAVANSHAD, MEHRDAD, MOHEBBI, SEYED REZA, & ZALI, MOHAMMAD REZA. (2016). ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B1 GENE POLYMORPHISM (RS401502 C/G) AND CHRONIC HEPATITIS B VIRUS INFECTION. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(3), 269-276. SID. https://sid.ir/paper/35916/en

Vancouver: Copy

SALEHI MOJTABA, RAVANSHAD MEHRDAD, MOHEBBI SEYED REZA, ZALI MOHAMMAD REZA. ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B1 GENE POLYMORPHISM (RS401502 C/G) AND CHRONIC HEPATITIS B VIRUS INFECTION. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(3):269-276. Available from: https://sid.ir/paper/35916/en

IEEE: Copy

MOJTABA SALEHI, MEHRDAD RAVANSHAD, SEYED REZA MOHEBBI, and MOHAMMAD REZA ZALI, “ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B1 GENE POLYMORPHISM (RS401502 C/G) AND CHRONIC HEPATITIS B VIRUS INFECTION,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 3, pp. 269–276, 2016, [Online]. Available: https://sid.ir/paper/35916/en

Related Journal Papers