LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B1 GENE POLYMORPHISM (RS11575934 A/G) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION

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SALEHI MOJTABA; MOHEBBI SEYED REZA; RAVANSHAD MEHRDAD; KARKHANE MARYAM; AZIMZADEH PEDRAM; KESHAVARZ PAKSERESHT BEHTA

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:18 | Issue:12 (105) Page(s): 51-58

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Title

LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B1 GENE POLYMORPHISM (RS11575934 A/G) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION

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Keywords

HEPATITIS B VIRUSQ2

SINGLE NUCLEOTIDE POLYMORPHISMQ1

IL-12 RECEPTOR B1Q2

CHRONIC HEPATITISQ2

Abstract

Background: HEPATITIS B VIRUS (HBV) is a member of hepadenaviridae family, which is infectious for humans and a few animal species. Successful clearance and elimination of infection from the body or development of HBV infection to chronic disease depend on the host genetic background in immune system genes. Interleukin-12 (IL12) and also Interleukin-12 Receptor B1 (IL 12 RB1) are the key factors in the spontaneous clearance of viral infections, especially HBV. The aim of the present research is to investigate the association between Interleukin-12 receptor B1 gene polymorphism (rs11575934 A/G) and susceptibility to chronic HEPATITIS B VIRUS infection.Materials and Methods: In this case- control study, genomic DNA of 150 chronic HBV infected patients and 150 healthy controls were extracted from peripheral blood cells. SINGLE NUCLEOTIDE POLYMORPHISM (rs11575934 A/G) was genotyped using polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).Results: The frequency of GG, AG, AA genotypes was 6.7%, 40.7%, and 52.7% in chronic patients and 12.7%, 41.3%, and 46% in control group, respectively. No statistically significant difference between case and control groups has been observed (p=0.176).Conclusion: In the present study, no significant correlation between rs11575934 A/G SINGLE NUCLEOTIDE POLYMORPHISM of the IL12RB1 gene and susceptibility to chronic HEPATITIS B VIRUS infection has been observed. According to the study, this polymorphism does not affect the susceptibility to chronic HBV infection.

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APA: Copy

SALEHI, MOJTABA, MOHEBBI, SEYED REZA, RAVANSHAD, MEHRDAD, KARKHANE, MARYAM, AZIMZADEH, PEDRAM, & KESHAVARZ PAKSERESHT, BEHTA. (2016). LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B₁ GENE POLYMORPHISM (RS11575934 A/G) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 18(12 (105)), 51-58. SID. https://sid.ir/paper/69857/en

Vancouver: Copy

SALEHI MOJTABA, MOHEBBI SEYED REZA, RAVANSHAD MEHRDAD, KARKHANE MARYAM, AZIMZADEH PEDRAM, KESHAVARZ PAKSERESHT BEHTA. LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B₁ GENE POLYMORPHISM (RS11575934 A/G) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;18(12 (105)):51-58. Available from: https://sid.ir/paper/69857/en

IEEE: Copy

MOJTABA SALEHI, SEYED REZA MOHEBBI, MEHRDAD RAVANSHAD, MARYAM KARKHANE, PEDRAM AZIMZADEH, and BEHTA KESHAVARZ PAKSERESHT, “LACK OF ASSOCIATION BETWEEN INTERLEUKIN-12 RECEPTOR B₁ GENE POLYMORPHISM (RS11575934 A/G) AND SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 18, no. 12 (105), pp. 51–58, 2016, [Online]. Available: https://sid.ir/paper/69857/en

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