ASSOCIATION BETWEEN INTERLEUKIN 10 GENE POLYMORPHISM (RS1800872A/C) AND CHRONIC HEPATITIS B INFECTION

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MIRFAKHAR FARZANEH SADAT; MOHEBBI SEYED REZA; HOSSEINI SEYED MASOUD; AZIMZADEH PEDRAM; DERAKHSHANI SHAGHAYEGH; SHARIFIAN AFSANEH; SARBAZI MOHAMAD REZA; ZALI MOHAMMAD REZA

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Journal: Razi Journal of Medical Sciences Year:2016 | Volume:23 | Issue:144 Page(s): 91-99

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Title

ASSOCIATION BETWEEN INTERLEUKIN 10 GENE POLYMORPHISM (RS1800872A/C) AND CHRONIC HEPATITIS B INFECTION

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Keywords

CYTOKINEQ2

SINGLE NUCLEOTIDE POLYMORPHISMQ2

INTERLEUKIN-10Q2

CHRONIC HEPATITIS BQ2

GENOTYPEQ2

Abstract

Background: CYTOKINEs are believed to play an important role in the regulation of cellular immune response in hepatitis B virus infection. Interleukin 10 is a member of CYTOKINE family. The overall expression of these molecules is mainly controlled by SINGLE NUCLEOTIDE POLYMORPHISMs at specific sites on the promoter region of the Interleukin 10 gene. The aim of this study was to analyze the association between Interleukin 10 gene SINGLE NUCLEOTIDE POLYMORPHISM (rs1800872A/C) and CHRONIC HEPATITIS B virus infection.Methods: A total of 130 CHRONIC HEPATITIS B virus infected patients and 130 healthy controls were involved in this study. Polymorphism detection and amplification was performed by Polymerase Chain Reaction (PCR) and genotyping was carried out by Restriction Fragment Length Polymorphism (RFLP).Results: GENOTYPE frequencies of CC, AC and AA were 40%, 50.8% and 9.2% for our patients and 56.9%, 36.2% and 6.9% in our control group, respectively. A statistically significant difference was observed in the frequency of Interleukin 10 gene polymorphism rs1800872A/C between healthy subjects and those with hepatitis B virus infection for both alleles (p=0.017) and GENOTYPE (p=0.025) frequencies.Conclusion: Interleukin 10 gene polymorphism rs1800872A/C could be a host genetic factor associated with susceptibility to hepatitis B virus infection or disease progression in CHRONIC HEPATITIS B virus infected patients.

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APA: Copy

MIRFAKHAR, FARZANEH SADAT, MOHEBBI, SEYED REZA, HOSSEINI, SEYED MASOUD, AZIMZADEH, PEDRAM, DERAKHSHANI, SHAGHAYEGH, SHARIFIAN, AFSANEH, SARBAZI, MOHAMAD REZA, & ZALI, MOHAMMAD REZA. (2016). ASSOCIATION BETWEEN INTERLEUKIN 10 GENE POLYMORPHISM (RS1800872A/C) AND CHRONIC HEPATITIS B INFECTION. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 23(144), 91-99. SID. https://sid.ir/paper/10074/en

Vancouver: Copy

MIRFAKHAR FARZANEH SADAT, MOHEBBI SEYED REZA, HOSSEINI SEYED MASOUD, AZIMZADEH PEDRAM, DERAKHSHANI SHAGHAYEGH, SHARIFIAN AFSANEH, SARBAZI MOHAMAD REZA, ZALI MOHAMMAD REZA. ASSOCIATION BETWEEN INTERLEUKIN 10 GENE POLYMORPHISM (RS1800872A/C) AND CHRONIC HEPATITIS B INFECTION. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;23(144):91-99. Available from: https://sid.ir/paper/10074/en

IEEE: Copy

FARZANEH SADAT MIRFAKHAR, SEYED REZA MOHEBBI, SEYED MASOUD HOSSEINI, PEDRAM AZIMZADEH, SHAGHAYEGH DERAKHSHANI, AFSANEH SHARIFIAN, MOHAMAD REZA SARBAZI, and MOHAMMAD REZA ZALI, “ASSOCIATION BETWEEN INTERLEUKIN 10 GENE POLYMORPHISM (RS1800872A/C) AND CHRONIC HEPATITIS B INFECTION,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 23, no. 144, pp. 91–99, 2016, [Online]. Available: https://sid.ir/paper/10074/en

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