Comparison of Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-veneris and apricot kernel extracts effects on the proliferation and apoptosis of breast cancer cells

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SOLTANI L.; DARBEMAMIEH M.

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Journal: JOURNAL OF CELL & TISSUE Year:2020 | Volume:11 | Issue:1 Page(s): 73-86

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Title

Comparison of Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-veneris and apricot kernel extracts effects on the proliferation and apoptosis of breast cancer cells

Author(s)

SOLTANI L. | DARBEMAMIEH M. | Issue Writer Certificate

Keywords

ApoptosisQ1

Breast cancer cellsQ1

CytotoxicityQ1

Herbal extractsQ2

Abstract

Aim: The aim of this study was to compare the anti-proliferative and apoptotic effects of hydroalcoholic extracts of different herbal medicines (Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-venerisand apricot kernel) against Breast cancer cells (Mcf-7). Material and method: For this purpose, the plants were dried and milled, then, soaked in 70% ethanol for 72 hours and their extracts were extracted using a rotary evaporator. Different concentrations of Herbal extracts (12. 5, 25, 50 and 100 μ g/ml) were added to the cancer cell culture medium and their Cytotoxicity and apoptotic effects were investigated after 24h by MTT assay and acridine orange-ethidium bromide staining, respectively. Data was analyzed by SPSS software at the significant level of 5%. Results: Addition of the highestconcentration of all extracts to the culture mediumshowed the most significant anti-proliferative and apoptotic effects (P<0. 05) compared to other concentrations of the same extracts. Also, among the high concentrations (100μ g/ml), the highest cell Cytotoxicity effects were related to the extracts of Echinacea purpureaand Adiantum capillus-veneris (P<0. 05). Conclusion: The results of this study indicated that the addition of Echinacea purpurea and Adiantum capillus-venerisextractsto the cell culturesin high concentrationshad the most significant anti proliferative and apoptotic effects on Breast cancer cells in comparison with other plant extractsand concentrations.

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APA: Copy

SOLTANI, L., & DARBEMAMIEH, M.. (2020). Comparison of Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-veneris and apricot kernel extracts effects on the proliferation and apoptosis of breast cancer cells. JOURNAL OF CELL & TISSUE, 11(1 ), 73-86. SID. https://sid.ir/paper/360286/en

Vancouver: Copy

SOLTANI L., DARBEMAMIEH M.. Comparison of Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-veneris and apricot kernel extracts effects on the proliferation and apoptosis of breast cancer cells. JOURNAL OF CELL & TISSUE[Internet]. 2020;11(1 ):73-86. Available from: https://sid.ir/paper/360286/en

IEEE: Copy

L. SOLTANI, and M. DARBEMAMIEH, “Comparison of Achillea wilhelmsii, Silybum marianumseed, Echinacea purpurea, Adiantum capillus-veneris and apricot kernel extracts effects on the proliferation and apoptosis of breast cancer cells,” JOURNAL OF CELL & TISSUE, vol. 11, no. 1 , pp. 73–86, 2020, [Online]. Available: https://sid.ir/paper/360286/en

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