THE TERATOGENIC EFFECTS OF ASPRIN AND ALCOHOL ON MOUSE EMBRYONIC DEVELOPMENT

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NAHANGI H.; MARZBAN H.; RAFIGHDOUST H.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2000 | Volume:8 | Issue:4 Page(s): 53-56

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Title

THE TERATOGENIC EFFECTS OF ASPRIN AND ALCOHOL ON MOUSE EMBRYONIC DEVELOPMENT

Author(s)

NAHANGI H. | MARZBAN H. | RAFIGHDOUST H. | Issue Writer Certificate

Keywords

ALCOHOLQ4

ASPRINQ4

FASQ4

MOUSEQ4

Abstract

ALCOHOL is a chemical substance which has side effect on embryo development. It can cause prenatal development, low birth weight, microcephally , mental retardation & facial anomalies. This condition is called fetus ALCOHOLic syndrome (FAS). Its pathogenic mechanism is unknown. One of the newest mechanism is that ALCOHOL elevates the level of blood prostaglandin in maternal tissue & embryo. High prostaglandin level is also teratogen. ASPRIN as an anti - inflammation and non stroidy pain killer may decrease the level of prostaglandin .Therefore ASPRIN can reduce the tratogenic effects of ALCOHOL. In this study, 135 mice were randomly divided into five groups of: G1 control, G2 Normal saline, G3 ALCOHOL, G4 ASPRIN, G5 ASPRIN and ALCOHOL on 7 to days of pregnancy. All embryos on day 18 were removed from the mice & were assessed according to their morphology, embryo toxicity, CRL (crawn ramp lenght). BPD (Biparital diameter). Growth factor & weight, Embryo toxicity in G5 was higher than -groups 3 & 4. , BPD, CRL, Weight & rowht height decreased in group 5 when compared with groups 3,4 and control. Our data showed that rate of anomaly in group 5 was higher than other groups. ASPRIN could decrease the blood prostaglandin level, but did not prevent the ALCOHOLic effect on embryo. In conclusion, the ALCOHOLic anomalies was related to some other factors including the prostaglandin.

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APA: Copy

NAHANGI, H., MARZBAN, H., & RAFIGHDOUST, H.. (2000). THE TERATOGENIC EFFECTS OF ASPRIN AND ALCOHOL ON MOUSE EMBRYONIC DEVELOPMENT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 8(4), 53-56. SID. https://sid.ir/paper/36106/en

Vancouver: Copy

NAHANGI H., MARZBAN H., RAFIGHDOUST H.. THE TERATOGENIC EFFECTS OF ASPRIN AND ALCOHOL ON MOUSE EMBRYONIC DEVELOPMENT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;8(4):53-56. Available from: https://sid.ir/paper/36106/en

IEEE: Copy

H. NAHANGI, H. MARZBAN, and H. RAFIGHDOUST, “THE TERATOGENIC EFFECTS OF ASPRIN AND ALCOHOL ON MOUSE EMBRYONIC DEVELOPMENT,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 4, pp. 53–56, 2000, [Online]. Available: https://sid.ir/paper/36106/en

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