TERATOGENIC EFFECTS OF SYNCHRONOUS ADMINISTRATION OF ALCOHOL AND ASPIRIN ON DEVELOPMENT OF SKELETAL SYSTEM IN MOUSE EMBRYO

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RAFIGHDOUST H.; AKBARI M.; MARZBAN H.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2001 | Volume:3 | Issue:2 Page(s): 0-0

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Title

TERATOGENIC EFFECTS OF SYNCHRONOUS ADMINISTRATION OF ALCOHOL AND ASPIRIN ON DEVELOPMENT OF SKELETAL SYSTEM IN MOUSE EMBRYO

Author(s)

RAFIGHDOUST H. | AKBARI M. | MARZBAN H. | Issue Writer Certificate

Keywords

ALCOHOLQ3

ASPIRINQ2

PROSTAGLANDINQ4

CONGENITAL ABNORMALITIESQ3

TERATOGENQ3

SKELETAL SYSTEMQ3

Abstract

New Page 1 Abnormalities caused by ALCOHOL are very extensive and are called fetal ALCOHOLic syndrome(FAS).There are some hypotheses about ALCOHOL and pathological mechanisms of its effect.Based on one of the recent hypotheses,ALCOHOL consumption can change matemal and fetal prostaglandin levels.On the other hand a strongprostaglandin inhibitor is ASPIRIN.Investigations which has done on mouse that received ALCOHOL and aspirin together,showed decrease in limbs length and kidney abnormalities in their offsprings.Others showed that ASPIRIN had no inhibition on ALCOHOL adverse effects.The aim of present study is to determine the effects of administration of ALCOHOL and Aspirin together.135 males and females ( 1 male versus 3 female) chose randomly divided in 5 groups. Afier vaginal plaque observation in 8th day of gestation, controls received nothing while other groups received suitable volumes of physiological serum, ALCOHOL, ASPIRIN, and a combination of ALCOHOL and Aspirin respectively by intraperitoneal injection. In 18th day of gestation, animals were killed by cervical dislocation. Embryos were collected, gross skeletal .system abnormalities were studied. There after staining was done by Alizarin Red and Alcian blue and ossification centers were counted in each group. Results showed that there are lower height and weight, and more skeletal .system abnonnalities in group that received a combination of ALCOHOL and Aspirin compared with the group that received ALCOHOL alone. Thus administration of Aspirin with ALCOHOL does not decrease frequency of skeletal abnormalities and probably there must be other factors, except PROSTAGLANDIN, involved in skeletal .system a bnormalities.

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APA: Copy

RAFIGHDOUST, H., AKBARI, M., & MARZBAN, H.. (2001). TERATOGENIC EFFECTS OF SYNCHRONOUS ADMINISTRATION OF ALCOHOL AND ASPIRIN ON DEVELOPMENT OF SKELETAL SYSTEM IN MOUSE EMBRYO. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 3(2), 0-0. SID. https://sid.ir/paper/364946/en

Vancouver: Copy

RAFIGHDOUST H., AKBARI M., MARZBAN H.. TERATOGENIC EFFECTS OF SYNCHRONOUS ADMINISTRATION OF ALCOHOL AND ASPIRIN ON DEVELOPMENT OF SKELETAL SYSTEM IN MOUSE EMBRYO. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2001;3(2):0-0. Available from: https://sid.ir/paper/364946/en

IEEE: Copy

H. RAFIGHDOUST, M. AKBARI, and H. MARZBAN, “TERATOGENIC EFFECTS OF SYNCHRONOUS ADMINISTRATION OF ALCOHOL AND ASPIRIN ON DEVELOPMENT OF SKELETAL SYSTEM IN MOUSE EMBRYO,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 3, no. 2, pp. 0–0, 2001, [Online]. Available: https://sid.ir/paper/364946/en

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