STRATEGY OF IMPROVEMENTS IN THE RAPEUTIC INDEX OF MEDICINAL HERBS OF IRANIANIN DIGENOUS: SYNTHESIS AND CHARACTERIZATION OF PHOSPHOLIPID LIPID-BASED VESICLES IN CORPORATED TRACHYSPERMUM COPTICUM

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Haghiralsadat Fatemeh; Azhdari Maryam; KALANTAR SEYED MEHDI; NADERINEZHAD SAMIRA; TEYMOURIZADEH KERAMAT; YAZDANI MOZHGAN; HASHEMI MOHADESEH; DANESHMAND FATEMEH

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:24 | Issue:6 Page(s): 468-478

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Title

STRATEGY OF IMPROVEMENTS IN THE RAPEUTIC INDEX OF MEDICINAL HERBS OF IRANIANIN DIGENOUS: SYNTHESIS AND CHARACTERIZATION OF PHOSPHOLIPID LIPID-BASED VESICLES IN CORPORATED TRACHYSPERMUM COPTICUM

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Keywords

PHOSPHOLIPID BASED VESICLEQ1

TRACHYSPERMUM COPTICUM ESSENTIAL OILQ1

ENCAPSULATIONQ1

ESSENTIAL OIL EXTRACTIONQ1

ANDTHYMOLQ2

Abstract

Introduction: Medicinal herbs are one of the most valuable Iranian National assets. Herbal essential oils have valuable therapeutic properties. Oxidation and volatile of essential oils caused some limitations in its usage. Nanoliposomes are nonometric lipid-based vesicles. Drug delivery carrier to improve delivery of therapeutic agent is one of the most well-known application of liposomal vesicles. In recent years, scientists paid much attention to encapsulate plant essential oil in nanocarriers. The goal of presented study was ENCAPSULATION of Trachyspermumcopticum in nanoliposomal carriers to improve the therapeutic functionality.Methods: The essential oil of Trachyspermumcopticum was extracted by Clevenger instrument using hydrodistilation method and its components were determined with gas-mass chromatography. Small unilamellar lipid based vesicles containing Trachyspermumcopticum essential oil were prepared using thin film hydration method. Lipid phase were contained SPC 80, cholesterol and Trachyspermumcopticum essential oil. Nano-vesicles were evaluated by several analyses such as ENCAPSULATION efficiency, size, zeta potential, release kinetic profile and surface morphology.Results: Results showed that the ENCAPSULATION efficiency of entrapped essential oil was 35.6±7.4% and mean nano-liposome diameter was 186.1 nm. The prepared nano-vesicle led to controlled release profile.Conclusion: In the present study, ENCAPSULATION of Trachyspermumcopticum essential oil into nano liposome was performed in order increasing stability, water- solubility and improving therapeutic index. The prepared formulation was slow-release, well-coating to preserve the essential oil against oxidation and increasing stability.

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APA: Copy

Haghiralsadat, Fatemeh, Azhdari, Maryam, KALANTAR, SEYED MEHDI, NADERINEZHAD, SAMIRA, TEYMOURIZADEH, KERAMAT, YAZDANI, MOZHGAN, HASHEMI, MOHADESEH, & DANESHMAND, FATEMEH. (2016). STRATEGY OF IMPROVEMENTS IN THE RAPEUTIC INDEX OF MEDICINAL HERBS OF IRANIANIN DIGENOUS: SYNTHESIS AND CHARACTERIZATION OF PHOSPHOLIPID LIPID-BASED VESICLES IN CORPORATED TRACHYSPERMUM COPTICUM. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(6), 468-478. SID. https://sid.ir/paper/36178/en

Vancouver: Copy

Haghiralsadat Fatemeh, Azhdari Maryam, KALANTAR SEYED MEHDI, NADERINEZHAD SAMIRA, TEYMOURIZADEH KERAMAT, YAZDANI MOZHGAN, HASHEMI MOHADESEH, DANESHMAND FATEMEH. STRATEGY OF IMPROVEMENTS IN THE RAPEUTIC INDEX OF MEDICINAL HERBS OF IRANIANIN DIGENOUS: SYNTHESIS AND CHARACTERIZATION OF PHOSPHOLIPID LIPID-BASED VESICLES IN CORPORATED TRACHYSPERMUM COPTICUM. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(6):468-478. Available from: https://sid.ir/paper/36178/en

IEEE: Copy

Fatemeh Haghiralsadat, Maryam Azhdari, SEYED MEHDI KALANTAR, SAMIRA NADERINEZHAD, KERAMAT TEYMOURIZADEH, MOZHGAN YAZDANI, MOHADESEH HASHEMI, and FATEMEH DANESHMAND, “STRATEGY OF IMPROVEMENTS IN THE RAPEUTIC INDEX OF MEDICINAL HERBS OF IRANIANIN DIGENOUS: SYNTHESIS AND CHARACTERIZATION OF PHOSPHOLIPID LIPID-BASED VESICLES IN CORPORATED TRACHYSPERMUM COPTICUM,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 6, pp. 468–478, 2016, [Online]. Available: https://sid.ir/paper/36178/en

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