Analysis of SEPT9 Gene Promoter Methylation Status in Esophageal Squamous Cell Carcinoma

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Mirza Aghasi Aida; Ghorbian Saied

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2020 | Volume:27 | Issue:10 Page(s): 1981-1992

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Information Journal Paper

Title

Analysis of SEPT9 Gene Promoter Methylation Status in Esophageal Squamous Cell Carcinoma

Author(s)

Mirza Aghasi Aida | Ghorbian Saied | Issue Writer Certificate

Keywords

MethylationQ1

Esophageal cancerQ3

ESCCQ1

SEPT9Q1

Abstract

Introduction: The changes in the level of SEPT9 gene promoter Methylation can contribute to the formation of esophageal squamous cell carcinoma. The aim of this study was to evaluate the level of changes in the level of SEPT9 gene promoter Methylation in the esophageal squamous cell carcinoma. Methods: In the present case-control study, we collected 75 paraffin blocks of Esophageal cancer tissues and 75 paraffin blocks healthy tissues, which were referred to the Noor-E-Nejat and Tabriz International Hospitals during 2013-2017. After DNA extraction and treatment with sodium metabisulfite, the changes of SEPT9 gene promoter Methylation assessed using high resolution melting (HRM) technique. The data were analyzed by SPSS 22 and Chi-square test. Results: Our findings did not show a statistically significant difference between the changes of SEPT9 gene promoter Methylation in cancer tissues compared to the healthy tissues (P=0. 106). Conclusion: This study shows that SEPT9 gene promoter Methylation cannot contribute to the esophageal squamous cell carcinoma cancerogenesis.

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APA: Copy

Mirza Aghasi, Aida, & Ghorbian, Saied. (2020). Analysis of SEPT9 Gene Promoter Methylation Status in Esophageal Squamous Cell Carcinoma. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(10 ), 1981-1992. SID. https://sid.ir/paper/36244/en

Vancouver: Copy

Mirza Aghasi Aida, Ghorbian Saied. Analysis of SEPT9 Gene Promoter Methylation Status in Esophageal Squamous Cell Carcinoma. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;27(10 ):1981-1992. Available from: https://sid.ir/paper/36244/en

IEEE: Copy

Aida Mirza Aghasi, and Saied Ghorbian, “Analysis of SEPT9 Gene Promoter Methylation Status in Esophageal Squamous Cell Carcinoma,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 10 , pp. 1981–1992, 2020, [Online]. Available: https://sid.ir/paper/36244/en

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