The expression of Hsa-miR-490 in peripheral blood circulation of patients with breast cancer

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Nikfarjam Amir Hassan; PORNOUR MAJID; Sohrabi Mojtaba

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Journal: Razi Journal of Medical Sciences Year:2020 | Volume:26 | Issue:10 Page(s): 87-94

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Title

The expression of Hsa-miR-490 in peripheral blood circulation of patients with breast cancer

Author(s)

Nikfarjam Amir Hassan | PORNOUR MAJID | Sohrabi Mojtaba | Issue Writer Certificate

Keywords

hsa-miR-490-5pQ2

OncomirQ1

Breast cancerQ1

FOXP3Q1

Abstract

Background: Cancer is the second most common cause of death after cardiovascular disease in worldwide and developed countries. Breast cancer is one of the major causes of mortality in women. Mortality from Breast cancer is significantly reduced with early detection. There are several detection methods. One way is investigate the changes of microRNA expression in serum / plasma. In this study, we examined the expression of hsa-miR-490 in serum that obtained from patients with Breast cancer. Methods: In a cross-sectional comparative study, peripheral blood samples were collected from 30 subjects with Breast cancer and 30 healthy individuals as a control group. Total mRNA was extracted from serum and cDNA was synthesized to study the hsa-miR-490-5p gene expression variations by real-time PCR. Results: Significant increase was observed in gene expression and sera concentration of hsa-miR-490-5p in serum of Breast cancer patient. Significant changes were not observed in gene expression of hsa-miR-490-3p in serum of Breast cancer patient. Conclusion: The obtained results indicated that hsa-miR-490-5p acts as Oncomir in serum by targeting FOXP3 (p<0. 05).

Cites

A review on microRNAs’ function, detection and evaluation methods, expression dysregulation mechanisms and possible applications in clinical phase as diagnostic, prognostic and therapeutic biomarkers of lung cancer patients

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APA: Copy

Nikfarjam, Amir Hassan, PORNOUR, MAJID, & Sohrabi, Mojtaba. (2020). The expression of Hsa-miR-490 in peripheral blood circulation of patients with breast cancer. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(10 ), 87-94. SID. https://sid.ir/paper/362568/en

Vancouver: Copy

Nikfarjam Amir Hassan, PORNOUR MAJID, Sohrabi Mojtaba. The expression of Hsa-miR-490 in peripheral blood circulation of patients with breast cancer. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2020;26(10 ):87-94. Available from: https://sid.ir/paper/362568/en

IEEE: Copy

Amir Hassan Nikfarjam, MAJID PORNOUR, and Mojtaba Sohrabi, “The expression of Hsa-miR-490 in peripheral blood circulation of patients with breast cancer,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 10 , pp. 87–94, 2020, [Online]. Available: https://sid.ir/paper/362568/en

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