Evaluating the clinical importance of long-non coding RNA MALAT1 expression in breast cancer

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Orangi Elham; MOTOVALI BASHI MAJID; TABATABAEIAN MARYAM

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:3 Page(s): 13-23

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Information Journal Paper

Title

Evaluating the clinical importance of long-non coding RNA MALAT1 expression in breast cancer

Author(s)

Orangi Elham | MOTOVALI BASHI MAJID | TABATABAEIAN MARYAM | Issue Writer Certificate

Keywords

Breast cancerQ2

LncRNAQ1

MALAT1Q1

BiomarkerQ1

Abstract

Background: Breast cancer is one of the major causes of illness and mortality among women. Long non-coding RNAs (LncRNAs) have important role in tumor development and progression. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a LncRNA that deregulates in several cancers, however, its value in the diagnosis of Breast cancer is unclear. This study was conducted to investigate the MALAT1 expression levels in breast tumor tissue, its association with tumor clinical featuresand its diagnostic value as a Biomarker in Breast cancer. Methods: In this study, the expression level of MALAT1 was measured in 31 breast tumor tissues and 31 adjacent normal tissues by real-time polymerase chain reaction. The MALAT1 expression alteration between the tumor and normal tissues and its association with clinical characteristics were analyzed with t-test and one-way ANOVA, respectively. The MALAT1 role as a Biomarker was investigated by ROC curve. Results: MALAT1 expression level in tumor tissues to adjacent normal tissues showed a significant decrement of 2. 87 times (fold change= 0. 348, p<0. 001). Also, there was a positive and significant correlation between MALAT1 expression and patientchr('39')s age and tumor invasive features (p <0. 05). The ROC curve results showed that the area under the curve was significant and equal to 0. 773. The sensitivity and specificity of MALAT1 as Biomarker were 71. 43 and 91. 67, respectively. Conclusion: The results of this study showed that the MALAT1 has a significant reduction in Breast cancer and can act as a Biomarker in diagnosing patients from healthy individuals.

Cites

The expression of Hsa-miR-490 in peripheral blood circulation of patients with breast cancer

References

Circulating long non-coding RNA MALAT1 expression as molecular biomarker in Egyptian patients with breast cancer

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APA: Copy

Orangi, Elham, MOTOVALI BASHI, MAJID, & TABATABAEIAN, MARYAM. (2019). Evaluating the clinical importance of long-non coding RNA MALAT1 expression in breast cancer. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(3 ), 13-23. SID. https://sid.ir/paper/395061/en

Vancouver: Copy

Orangi Elham, MOTOVALI BASHI MAJID, TABATABAEIAN MARYAM. Evaluating the clinical importance of long-non coding RNA MALAT1 expression in breast cancer. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(3 ):13-23. Available from: https://sid.ir/paper/395061/en

IEEE: Copy

Elham Orangi, MAJID MOTOVALI BASHI, and MARYAM TABATABAEIAN, “Evaluating the clinical importance of long-non coding RNA MALAT1 expression in breast cancer,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 3 , pp. 13–23, 2019, [Online]. Available: https://sid.ir/paper/395061/en

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