A STUDY OF THE EFFECT OF ORAL CLONIDINE ON PROLONGATION OF POST OPERATIVE PAIN- FREE PERIOO IN CHILDREN RECEIVING CAUDAL ANAESTHESIA

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HOSSEINI H.; ABASI H.R.; MAHDAVIAN A.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2002 | Volume:10 | Issue:3 SUPPLEMENT Page(s): 46-50

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Title

A STUDY OF THE EFFECT OF ORAL CLONIDINE ON PROLONGATION OF POST OPERATIVE PAIN- FREE PERIOO IN CHILDREN RECEIVING CAUDAL ANAESTHESIA

Author(s)

HOSSEINI H. | ABASI H.R. | MAHDAVIAN A. | Issue Writer Certificate

Keywords

CAUDAL ANAESTHESIAQ4

CLONIDINEQ3

BUPIVACAINEQ3

Abstract

Post operative pain can be a major source of fear and anxiety in hospitalized patients leading to so many complications including pulmonary , cardiovascular gastro – intestinal , urinary dysfunction , impairment of muscle metabolism and function , neuroendocrine , metabolic changes and many other complications. Therefore control of post operative pain, especially in children is very important. Caudal bupivacain analgesia is a very effective method for controlling post operative pain, but premedication with oral CLONIDINE may improve the quality and duration of bupivacain caudal analgesia. In this study, effect of oral CLONIDINE on the duration of caudal BUPIVACAINE analgesia was studied in 60 children in the age group 3-8 years. All of them were subjected to ortheopedic, urologic and surgical procedures of the lower extremities. All patients received caudal BUPIVACAINE anesthesia (0.25%) after the induction of anesthesia at the dose of 2mg/kg.Anesthesia was induced with halothane, N20 and O2 and maintained throughout the procedure. 30 patients received 5 µy/kg oral CLONIDINE and 30 patients received placebo 1.5 hour before caudal anesthesia . Patients were assessed for duration of analgesia and the time and dosage of receiving the first analgesic drug postoperatively. Blood pressure and HR of patients were recorded at equal intervals from the time of receiving CLONIDINE . In addition to age, sex and weight of patients were recorded to study presence of any relationship between them and duration of analgesia.The following results were recorded: Both groups were almost similar in regard to sex ,age and weight. There was no effect of age, sex and weight on the duration of caudal BUPIVACAINE analgesia. Patients of CLONIDINE group were remarkably more hypotensive as compared to the placebo group but the occurence of bradycardia was the same in both groups.The duration of pain relief was 1.9 times more in CLONIDINE group as compared to placebo group (The average time of receiving the first dose of analgesia post operatively in placebo group and CLONIDINE group was 293 ± 30 and 433 ± 155 minutes respectively. Therefore, it is recommended that oral CLONIDINE (5 mg/kg) should be adminstered 1 1/2 hours before caudal BUPIVACAINE analgesia for induction of a good quality and long duration analgesia in children post operatively.

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APA: Copy

HOSSEINI, H., ABASI, H.R., & MAHDAVIAN, A.. (2002). A STUDY OF THE EFFECT OF ORAL CLONIDINE ON PROLONGATION OF POST OPERATIVE PAIN- FREE PERIOO IN CHILDREN RECEIVING CAUDAL ANAESTHESIA . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 10(3 SUPPLEMENT), 46-50. SID. https://sid.ir/paper/36290/en

Vancouver: Copy

HOSSEINI H., ABASI H.R., MAHDAVIAN A.. A STUDY OF THE EFFECT OF ORAL CLONIDINE ON PROLONGATION OF POST OPERATIVE PAIN- FREE PERIOO IN CHILDREN RECEIVING CAUDAL ANAESTHESIA . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;10(3 SUPPLEMENT):46-50. Available from: https://sid.ir/paper/36290/en

IEEE: Copy

H. HOSSEINI, H.R. ABASI, and A. MAHDAVIAN, “A STUDY OF THE EFFECT OF ORAL CLONIDINE ON PROLONGATION OF POST OPERATIVE PAIN- FREE PERIOO IN CHILDREN RECEIVING CAUDAL ANAESTHESIA ,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 3 SUPPLEMENT, pp. 46–50, 2002, [Online]. Available: https://sid.ir/paper/36290/en

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