THE EFFECT OF CHOLECYSTOKININ ON ESOPHAGEAL MUSCLE OF RABBIT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DASHTI M.H.; MORSHEDI A.; FALAHZADEH M.H.; NAZAMI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2001 | Volume:9 | Issue:3 Page(s): 44-51

Download Full-Text

Persian Verion

View:

1,829

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF CHOLECYSTOKININ ON ESOPHAGEAL MUSCLE OF RABBIT

Author(s)

DASHTI M.H. | MORSHEDI A. | FALAHZADEH M.H. | NAZAMI A. | Issue Writer Certificate

Keywords

CHOLECYSTOKININ (C.C.K)Q2

SMOOTH MUSCLEQ4

THRACHEAQ4

RABBITQ4

Abstract

There are many chemical receptors in the membrane of the tracheal SMOOTH MUSCLE cells through which different neurotransmitters and chemical agents affect them and result in an increase or decrease of airway resistance. Bronchial constriction is a relatively increasing symptom due to air pollution , thus many investigators are trying to find the agents that are involved in bronchoconstriction. Cholecystokinin (C.C.K) is one of these agents that is released from the nerve endings in the airways , but the function of this polypeptide is not known yet. In this study , isolated tracheal specimens lengthing about 5 cm were mounted in anoryan bath filled with krebs solution. Electrical stimulations in different voltage (10-30 V) and frequencies (20 - 60 Hz) were applied to the lower end of the specimens via a bipolar silver stimulatory electrode , and any altration in the tracheal length and tracheal pressure were recorded by using an isotonic transducer and a pressure transducer connected to a two channel oscilograph.To assess the effect of C.C.K on RABBITs tracheal SMOOTH MUSCLE , different concentrations of C.C.K was added to the solution bathing the specimens. Our data showed that C.C.K alone had no effect on the tracheal SMOOTH MUSCLE but could potentiate the effect of electrical stimulation in a voltage and frequency dependent manner. This effect was also concentrations dependent up to 10-7 molar (C.C.K) which showed the maximum effect on tracheal length and intratracheal pressure which (0.01). were increased significantly from dose of the control (Since different concentrations of C.C.K had no on tracheal smooth muscles by themselves but they augmented the responce to electrical stimulation suggest that C.C.K may act as a neuromodulator in the respiratory airways.

Cites

No record.

References

No record.

Cite

APA: Copy

DASHTI, M.H., MORSHEDI, A., FALAHZADEH, M.H., & NAZAMI, A.. (2001). THE EFFECT OF CHOLECYSTOKININ ON ESOPHAGEAL MUSCLE OF RABBIT . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 9(3), 44-51. SID. https://sid.ir/paper/36341/en

Vancouver: Copy

DASHTI M.H., MORSHEDI A., FALAHZADEH M.H., NAZAMI A.. THE EFFECT OF CHOLECYSTOKININ ON ESOPHAGEAL MUSCLE OF RABBIT . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;9(3):44-51. Available from: https://sid.ir/paper/36341/en

IEEE: Copy

M.H. DASHTI, A. MORSHEDI, M.H. FALAHZADEH, and A. NAZAMI, “THE EFFECT OF CHOLECYSTOKININ ON ESOPHAGEAL MUSCLE OF RABBIT ,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 3, pp. 44–51, 2001, [Online]. Available: https://sid.ir/paper/36341/en

Related Journal Papers