EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS L. SEED ON TRACHEAL SMOOTH MUSCLE CONTRACTIONS IN MALE RATS

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JAFARZADE PARASTOO; MOHSENI MEHRAN SEYED MOHAMMAD; MOLADOUST HASSAN; NORASFARD MOHAMMAD REZA; GHORBANI AHMAD; ABEDINZADE MAHMOOD

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Title

EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS L. SEED ON TRACHEAL SMOOTH MUSCLE CONTRACTIONS IN MALE RATS

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Keywords

ANETHUM GRAVEOLENSQ2

SMOOTH MUSCLEQ2

AIRWAYQ1

Abstract

Background and purpose: AIRWAY stenosis is one the most dangerous diseases. Anethumgraveolens L. (Dill) has anti-spastic effect on SMOOTH MUSCLE. The aim of this study was to investigate theeffect of the hydroalcoholic extract of this plant on male rat tracheal SMOOTH MUSCLE contractile activity. Materials and methods: In this experimental study, tracheas of healthy rats were dissected. Weinvestigated the effect of different concentrations of Dill hydroalcoholic extract in presence and absenceof propranolol and L-NAME on reduction of tracheal SMOOTH MUSCLE contraction induced by potassiumchloride. Results: Compared with the negative and positive control groups, the extract of Anethumgraveolens at 5 gr/l significantly decreased tracheal SMOOTH MUSCLE contraction induced by potassiumchloride (P <0. 05). Propranolol and L-NAME did not reduce the antispasmodic effect of Dill extract(P<0. 05). Conclusion: Hydroalcoholic extract of ANETHUM GRAVEOLENS could inhibit the tracheal smoothmuscle of rat contractions in a dose-dependent manner, but it seems that β-Adrenergic receptors and NOare not involved in this process.

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APA: Copy

JAFARZADE, PARASTOO, MOHSENI MEHRAN, SEYED MOHAMMAD, MOLADOUST, HASSAN, NORASFARD, MOHAMMAD REZA, GHORBANI, AHMAD, & ABEDINZADE, MAHMOOD. (2018). EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS L. SEED ON TRACHEAL SMOOTH MUSCLE CONTRACTIONS IN MALE RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(160 ), 146-150. SID. https://sid.ir/paper/45196/en

Vancouver: Copy

JAFARZADE PARASTOO, MOHSENI MEHRAN SEYED MOHAMMAD, MOLADOUST HASSAN, NORASFARD MOHAMMAD REZA, GHORBANI AHMAD, ABEDINZADE MAHMOOD. EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS L. SEED ON TRACHEAL SMOOTH MUSCLE CONTRACTIONS IN MALE RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(160 ):146-150. Available from: https://sid.ir/paper/45196/en

IEEE: Copy

PARASTOO JAFARZADE, SEYED MOHAMMAD MOHSENI MEHRAN, HASSAN MOLADOUST, MOHAMMAD REZA NORASFARD, AHMAD GHORBANI, and MAHMOOD ABEDINZADE, “EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS L. SEED ON TRACHEAL SMOOTH MUSCLE CONTRACTIONS IN MALE RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 160 , pp. 146–150, 2018, [Online]. Available: https://sid.ir/paper/45196/en

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