EFFECT OF CURCUMIN ON ANGIOGENESIS IN AORTIC RING MODEL OF THE WISTAR RAT

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BAHARARA J.; MOUSAVI M.; RAMEZANI T.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2014 | Volume:22 | Issue:3 Page(s): 1226-1236

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Information Journal Paper

Title

EFFECT OF CURCUMIN ON ANGIOGENESIS IN AORTIC RING MODEL OF THE WISTAR RAT

Author(s)

BAHARARA J. | MOUSAVI M. | RAMEZANI T. | Issue Writer Certificate

Keywords

ANGIOGENESISQ2

AORTAQ1

CURCUMINQ3

RATQ2

Abstract

Introduction: Tumeric is a plant with both food and medical properties by which CURCUMIN is derived from. It has various pharmacological effects. ANGIOGENESIS, a dynamic process of endothelial cells proliferation in order to develop new blood vessels from the previous ones, affects a wide range of physiological and pathological processes such as tumor growth and metastasis. In this study, anti angiogenic effects of Cucumin were investigated in aortic ring of Wistar RATs.Methods: In this experimental study, Aortic ring was cut up in to 1 mm pieces and cultured in collagen matrix. After three days, sprouting ANGIOGENESIS were observed, and then aortic rings were treated with CURCUMIN at concentration of 25, 50 and 100 mg/ml. Effects of treatment in all cases were photographed and then investigated by invert microscope. Lengths of vessels were measured by Image J software. Moreover, the study data were analyzed using SPSS in significant level of P<0.05.Result: Data analysis revealed that no significant difference was observed in regard with average of length and number of blood vessels in the control group compared with sham-exposed group (P>0.05). In fact, average length and number of blood vessels in experimental group 1 demonstrated no significant difference compared with control group, though in the experimental group 2 (79.45±3.2mm), (12±1.3) and 3 (38.93±1.1mm), (8±1.1) significant differences were observed (P<0.05).Conclusion: The results proposed that the CURCUMIN had dose-dependent inhibitory effects on ANGIOGENESIS in RAT aortic ring Therefore, it can be introduced as an appropriate candidate in order to study ANGIOGENESIS and related diseases.

Cites

INVESTIGATION THE EFFECT OF CURCUMIN ON THE HORMONES OF PITUITARY-OVARIAN AXIS IN ALLOXAN-INDUCED DIABETIC RATS

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APA: Copy

BAHARARA, J., MOUSAVI, M., & RAMEZANI, T.. (2014). EFFECT OF CURCUMIN ON ANGIOGENESIS IN AORTIC RING MODEL OF THE WISTAR RAT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 22(3), 1226-1236. SID. https://sid.ir/paper/36408/en

Vancouver: Copy

BAHARARA J., MOUSAVI M., RAMEZANI T.. EFFECT OF CURCUMIN ON ANGIOGENESIS IN AORTIC RING MODEL OF THE WISTAR RAT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(3):1226-1236. Available from: https://sid.ir/paper/36408/en

IEEE: Copy

J. BAHARARA, M. MOUSAVI, and T. RAMEZANI, “EFFECT OF CURCUMIN ON ANGIOGENESIS IN AORTIC RING MODEL OF THE WISTAR RAT,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 3, pp. 1226–1236, 2014, [Online]. Available: https://sid.ir/paper/36408/en

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