ANTI-ANGIOGENIC EFFECT OF AQUEOUS EXTRACT OF SHALLOT (ALLIUM ASCALONICUM) BULBS IN RAT AORTA RING MODEL

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MOHAMMADI MOTLAGH H.R.; MANSOURI K.; SHAKIBA Y.A.; KESHAVARZ MARYAM; KHODARAHMI R.; SIAMI ABAS; MOSTAFAEI ALI

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Journal: Cell Journal (Yakhteh) Year:2009 | Volume:11 | Issue:2 (42) Page(s): 190-195

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Title

ANTI-ANGIOGENIC EFFECT OF AQUEOUS EXTRACT OF SHALLOT (ALLIUM ASCALONICUM) BULBS IN RAT AORTA RING MODEL

Author(s)

Keywords

ANGIOGENESISQ1

ALLIUM ASCALONICUMQ1

AORTIC RINGSQ1

ENDOTHELIAL CELLSQ1

AQUEOUS EXTRACTQ1

Abstract

Objective: ANGIOGENESIS is a key process in the promotion of cancer and its metastasis. Many natural health products inhibit ANGIOGENESIS. Because of the lack of molecular studies on anti-tumor and anti-angiogenic effects of shallot (Allium ascalonicum); except a few clinical studies on other shallot properties, such as the anti-proliferative effect of shallot chloroformic extract on two tumor cell lines, the present study focuses on the anti-angiogenic effect of aqueous shallot extract using an aorta ring model.Materials and Methods: AORTIC RINGS were obtained by cross-sectioning, at 1-2 mm intervals, the thoracic aorta of 4-8 weeks old Wistar male rats and cultured them in a thin drop of type I collagen gel. After 3 days of culturing and first sprouting, the extract of A. ascalonicum (from 25 to 800mg/ml) was added to cultures. The results of anti-angiogenic activity were investigated by microscope. The cytotoxicity of extract at different doses on HUVECs was measured by trypan blue assay.Results: The results showed that the shallot extract has suitable anti-angiogenic effect in a range of 50 to 800mg/ml, but in 25mg/ml, the extract has no considerable effect. In addition, a tangible cytotoxic effect on ENDOTHELIAL CELLS at the above mentioned doses was observed.Conclusion: Our study showed that AQUEOUS EXTRACT of A. ascalonicum bulbs has noticeable anti-angiogenic activity without toxic effect on the cells in doses that ranged from 50-800mg/ml. Therefore, A. ascalonicum can be a potential candidate for further investigations used in ANGIOGENESIS-related pathologic conditions.

Cites

EFFECT OF CURCUMIN ON ANGIOGENESIS IN AORTIC RING MODEL OF THE WISTAR RAT

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APA: Copy

MOHAMMADI MOTLAGH, H.R., MANSOURI, K., SHAKIBA, Y.A., KESHAVARZ, MARYAM, KHODARAHMI, R., SIAMI, ABAS, & MOSTAFAEI, ALI. (2009). ANTI-ANGIOGENIC EFFECT OF AQUEOUS EXTRACT OF SHALLOT (ALLIUM ASCALONICUM) BULBS IN RAT AORTA RING MODEL. CELL JOURNAL (YAKHTEH), 11(2 (42)), 190-195. SID. https://sid.ir/paper/16409/en

Vancouver: Copy

MOHAMMADI MOTLAGH H.R., MANSOURI K., SHAKIBA Y.A., KESHAVARZ MARYAM, KHODARAHMI R., SIAMI ABAS, MOSTAFAEI ALI. ANTI-ANGIOGENIC EFFECT OF AQUEOUS EXTRACT OF SHALLOT (ALLIUM ASCALONICUM) BULBS IN RAT AORTA RING MODEL. CELL JOURNAL (YAKHTEH)[Internet]. 2009;11(2 (42)):190-195. Available from: https://sid.ir/paper/16409/en

IEEE: Copy

H.R. MOHAMMADI MOTLAGH, K. MANSOURI, Y.A. SHAKIBA, MARYAM KESHAVARZ, R. KHODARAHMI, ABAS SIAMI, and ALI MOSTAFAEI, “ANTI-ANGIOGENIC EFFECT OF AQUEOUS EXTRACT OF SHALLOT (ALLIUM ASCALONICUM) BULBS IN RAT AORTA RING MODEL,” CELL JOURNAL (YAKHTEH), vol. 11, no. 2 (42), pp. 190–195, 2009, [Online]. Available: https://sid.ir/paper/16409/en

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