Study Effects of Staphylococcus aureus Superantigen C on Production of CReactive Protein in Rat

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ataee M.R.; ALISHIRI GH.; Hesampoor Mahalati A.; ATAEE R.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Armaghane Danesh Year:2019 | Volume:24 | Issue:4 (135) Page(s): 612-625

Download Full-Text

Persian Verion

View:

286

Download:

Cites:

Information Journal Paper

Title

Study Effects of Staphylococcus aureus Superantigen C on Production of CReactive Protein in Rat

Author(s)

Ataee M.R. | ALISHIRI GH. | Hesampoor Mahalati A. | ATAEE R.A. | Issue Writer Certificate

Keywords

PurificationQ3

Superantigen CQ1

Staphylococcus AureusQ2

C-Reactive ProteinQ1

Rheumatoid ArthritisQ1

Abstract

Background & aim: Microbial super antigens have reported in blood and synovial fluid of Rheumatoid Arthritis patients. Whether or not, the presence of these super antigens could provoke the induction of serologic diagnostic factors, including CRP in patients? the purpose of this study was to production and Purification one of the super antigen C of Staphylococcus Aureus and it ʹ s effect on the induction of CRP in rat Methods: In this experimental study which was performed from December 2017 to September 2018 at the Baqiyatallah University of Medical Sciences. Twenty Wistar rats weighing 250 to 300 Grams were selected and divided into four groups of 5 members, included. By participated to workshops of animal laboratory control as well as intraperitoneal and intera-articular injection were carried out. Staphylococcus Aureus super antigen C was purified by ultrafiltration (Amicon Ultra Centrifugal Filter Device) form 24 hours culture media and use specific antibody for immunoblotting confirmatory was carried out. The protein concentration was measured. 50 micrograms of toxin were injected intraperitoneal and intra-articular into separate rat groups. In time course blood collection and CRP was tested. The results were analyzed. Results: The results showed that 50 to 100 μ g of toxin intra-articular and intraperitoneal after 20 days inducted CRP production at 0. 7 mg. After 40 days, this increased to 2. 2 mg/lit and after 50 days it reached to 4. 5 mg/lit. ANOVA analysis was shown the difference between the groups and with a significant level for groups was P≤ 0. 001 and for the intervals of the effect of super antigen was P≤ 0. 075, respectively. Conclusion: The results indicate that the presence and survival of staphylococcal super antigen C in the body of wistar rats induced the production of CRP factor. Although this finding is an introduction to further research, it is likely to provide new ways to prevent and control inflammatory diseases, including Rheumatoid Arthritis.

Cites

No record.

References

Cite

APA: Copy

Ataee, M.R., ALISHIRI, GH., Hesampoor Mahalati, A., & ATAEE, R.A.. (2019). Study Effects of Staphylococcus aureus Superantigen C on Production of CReactive Protein in Rat. ARMAGHAN DANESH, 24(4 (135) ), 612-625. SID. https://sid.ir/paper/365297/en

Vancouver: Copy

Ataee M.R., ALISHIRI GH., Hesampoor Mahalati A., ATAEE R.A.. Study Effects of Staphylococcus aureus Superantigen C on Production of CReactive Protein in Rat. ARMAGHAN DANESH[Internet]. 2019;24(4 (135) ):612-625. Available from: https://sid.ir/paper/365297/en

IEEE: Copy

M.R. Ataee, GH. ALISHIRI, A. Hesampoor Mahalati, and R.A. ATAEE, “Study Effects of Staphylococcus aureus Superantigen C on Production of CReactive Protein in Rat,” ARMAGHAN DANESH, vol. 24, no. 4 (135) , pp. 612–625, 2019, [Online]. Available: https://sid.ir/paper/365297/en

Related Journal Papers